Molecular Genetic Analysis Core

研究皮肤病的研究人员的一个基本需求是进行一些不同的分子遗传学 技术，包括绘制、识别和表征基因的能力，涉及皮肤分化、皮肤 发展、皮肤损伤和皮肤病。这些分析需要使用专门的高成本设备 以及训练有素的专业人员，他们的专业知识超出了大多数个人的一般水平 研究实验室。UCD-SDRC分子遗传分析核心的目标是提供研究人员 拥有必要的工具和专业知识，用于大规模和较小规模的、用户定义的基因分型 多态遗传标记，大规模和小规模DNA测序，以及全基因组、多基因和 单基因RNA表达分析。这些技术中的每一项都需要昂贵的设备和 专业知识，UCD-SDRC分子遗传分析核心将协调几个现有OnCampus之间的访问 拥有并运营所有这些技术所需设备的核心设施，以提供 以折扣价向UCD-SDCR成员提供这些服务，而不是 这些核心实验室提供的服务或商业实体提供的这些服务的成本。此外，UCD-SDRC 分子遗传分析核心将为研究人员提供基因研究设计方面的专业知识，以便 优化使用有价值的患者样本和资源，使研究人员能够回答重要研究 关于皮肤病的问题。

A fundamental need of investigators studying skin disease is to carry out a number of different molecular genetic technologies, including the ability to map, identify, and characterize genes involve in skin differentiation, skin development, skin damage, and skin disease. These analyses require access to specialized high-cost equipment and highly trained personnel with specialized expertise, beyond what is typically available in most individual research laboratories. The objective of the UCD-SDRC Molecular Genetic Analysis Core is to provide investigators with the necessary tools and expertise for both large-scale and smaller-scale, user-defined genotyping of polymorphic genetic markers, large-scale and small-scale DNA sequencing, and for genomewide, multi-gene, and single-gene RNA expression analyses. Each of these technologies requires high-cost items of equipment and expertise, and the UCD-SDRC Molecular Genetic Analysis Core will coordinate access among several existing oncampus core facilities that own and operate the equipment necessary for all of these technologies, to provide these services to UCD-SDCR members at discount pricing compared to either the unsubsidized cost of these services from these core labs or the cost of these services from commercial entities. In addition, the UCD-SDRC Molecular Genetic Analysis Core will provide expertise to investigators in design of genetic studies, so as to optimize use of valuable patient samples and resources to allow investigators to answer important research questions in skin disease.