National Institute on Aging (NIA) Colony

灵长类动物服务：老年群体研究所 摘要 灵长类动物服务的主要目标是确保加州最高质量的动物护理和饲养 国家灵长类动物研究中心（CNPRC）非人灵长类动物群。CNPRC针对两个 猕猴种群，以支持老年猕猴资源。第一个群体是 "招募"动物，已达到15岁，很少或没有实验用途， 天真。在19岁时，这些招募动物进入由所有恒河猴组成的老年恒河猴群体 19岁或以上CNPRC的NIA对老年猴子的支持目前约为107，000美元 费用/年，支持约28只19岁以上猴子的每日津贴， 到衰老研究。虽然NIA的投资对当地和国家研究团队都很有帮助， 对老龄化感兴趣，它只涵盖了支持我们的目标殖民地所需资金的一小部分， 大约64万美元。因此，一个可行的计划，在老龄化，具有全国范围内需要一个显着的扩大 这个资源。我们一直试图维持100只19岁以上的恒河猴用于研究 以及100只"招募"猴子（15 - 18岁）。不过，P51基地没有指定基金 超过107，000美元的NIA。这对我们的P51赠款造成了极大的财务压力，特别是 在过去的5 - 7年里，P51预算下降或持平。因此，我们要求在这一修订的P51中提供资金， 建议支持90只老年猴子和100只正在老化的猴子的全部补充。这 一个保护区将不仅为整个190只猴子提供保护（而目前只支持28只 老年猴），但也将允许在一个扩展的年龄组进行持续的纵向研究， 对于揭示一组预测脆弱性的生物标志物（即，一项猴子脆性研究）。我们 预计这些额外的资金将直接由NIA提供，作为其现有资金的扩展。 支持，而不是主任办公室。具体目标如下：（1）支持和 将国立衰老研究所的恒河猴分为两组（中年、老年）供研究者使用 （2）建立和维护一个纵向数据库， 这两个种群都是在每两年一次的体检和动物生命史的某些里程碑时收集的， 以及（3）为地方、区域和国家层面的调查人员提供高质量的专业知识和服务。

PRIMATE SERVICES: NATIONAL INSTITUTE ON AGING COLONY ABSTRACT The primary goal of Primate Services is to ensure the highest quality animal care and husbandry for the California National Primate Research Center (CNPRC) nonhuman primate colonies. The CNPRC has targeted two populations of rhesus macaques to support the aged rhesus macaque resource. The first group is a colony of “recruitment” animals that have reached 15 years of age with minimal or no experimental use and are surgery naïve. At 19 years of age these recruitment animals enter the aged rhesus colony which consists of all rhesus 19 years or older. NIA support for aged monkeys at CNPRC is currently approximately $107,000 direct costs/year, which supports the per diem for approximately 28 monkeys over 19 years of age that are committed to aging research. While this NIA investment has been very helpful to both local and national research teams interested in aging, it only covers a small portion of the funds required to support our target colony which requires approximately $640,000. Thus, a viable program in aging that has national reach requires a dramatic expansion of this resource. We have been attempting to maintain 100 rhesus monkeys over 19 years of age for research as well as 100 “recruitment” monkeys (15-18 years). However, there are no designated funds in the P51 base grant beyond the $107,000 from NIA. This results in extreme financial pressure on our P51 grant, particularly with the declining or flat P51 budgets over the past 5-7 years. Thus, we are requesting funds in this revised P51 proposal to support the full complement of 90 geriatric monkeys and 100 monkeys in the aging pipeline. This colony will not only provide protection for the entire group of 190 monkeys (versus the current support for 28 aged monkeys), but will also allow for ongoing longitudinal studies across an extended age group that will be essential to reveal a panel of biomarkers predictive of vulnerability (i.e., a monkey Framingham Study). Our expectation is that these additional funds will be provided directly by NIA as an expansion of their current support, and not from the Office of the Director. The following Specific Aims are proposed: (1) Support and maintain National Institute on Aging rhesus monkeys in two groups (middle aged, aged) for investigators nationwide that are conducting aging-related research, (2) Establish and maintain a longitudinal database on both populations that are collected at bi-annual physicals and at certain milestones in the animals’ life history, and (3) Provide high quality expertise and services to investigators at the local, regional, and national levels.