Training in Microbial Pathogenesis and Genomics

这份申请是我们的微生物致病和基因组学培训计划的新提交，该计划 之前在2006-2016年间得到了T32的支持。我们请求为五名博士前实习生提供支持 每年。该项目设在宾夕法尼亚大学和宾夕法尼亚大学儿童医院。 费城位于一个连续的校园内，包括12个由Well- 常设首席调查员和三名“初级调查员”，他们是新任命的助理 教授们。基于之前资助计划的成功，这款T32将使我们能够继续 从宾夕法尼亚大学的人才库和充满活力的生物医学学院招募一些最优秀、最聪明的实习生 为学生提供大量优秀研究机会的环境。有组织的人 这个T32的培训任务帮助我们努力作为一个团队更有效地合作和互动；我们的 培训者有几个联合的NIH赠款，许多联合出版物和一个强大的合作网络， 让我们的实习生参与进来。我们在微生物学计划内正在进行的研究会议和研讨会 帮助刺激了令人兴奋的、在细菌发病机制、微生物方面的协作工作的快速增长 免疫病理机制和细菌元基因组学，以及对深度测序设施的机构支持， 生物信息学，以及无菌小鼠核心在这些努力中发挥着重要作用。这些资源有 已扩展到新的宾夕法尼亚-CHOP微生物组计划，该计划将成为新的 在我们的T32中进行研究和合作。我们以前资助的项目的保留率是完美的； 在10年的资助期间，没有一名学员过早离开该项目。另外，我们所有以前的实习生 继续在微生物学或与传染病密切相关的领域工作。我们的五个人 之前的学员都获得了终身教职--都是在主要大学。这项研究 培训师在该计划中提供的机会，再加上坚定的机构承诺和 广泛而有组织的培训计划将继续提供出色的博士前培训 微生物发病机制和基因组学。

This application is a new submission for our Microbial Pathogenesis and Genomics training program, which was previously supported by a T32 from 2006-2016. We are requesting support for five predoctoral trainees per year. The program, which is based at the University of Pennsylvania and Children's Hospital of Philadelphia and is located on a single contiguous campus, includes twelve laboratories directed by well- established principle investigators and three "junior investigators", who are newly appointed assistant professors. Based on the success of the previously funded program, this T32 will enable us to continue to recruit some of the best and brightest trainees from a talented pool at Penn and from a vibrant biomedical environment that offers a large number of outstanding research opportunities for students. The organized training mission of this T32 has helped our efforts to collaborate and interact more effectively as a group; our trainers have several joint NIH grants, numerous joint publications, and a network of robust collaborations that involve our trainees. Our research in progress meetings and seminars within the microbiology program have helped spur the rapid growth of exciting, collaborative work in bacterial pathogenesis, microbial immunopathogenesis, and bacterial metagenomics, with institutional support for deep-sequencing facilities, bioinformatics, and a germ-free mouse core playing important roles in these efforts. These resources have been expanded to the new Penn-CHOP Microbiome Program, which will be a major focal point for new research and collaborations within our T32. The retention rate of our previously funded program was perfect; no trainee left the program prematurely over the 10 years of funding. In addition, all of our former trainees have continued to work in Microbiology or closely related fields involving infectious diseases. Five of our previous trainees have obtained tenure-track faculty positions – all at major universities. The research opportunities provided by the trainers in this program coupled with strong institutional commitment and an extensive and well-organized training program will continue to provide excellent predoctoral training in microbial pathogenesis and genomics.