THE MANHATTAN HIV BRAIN BANK

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 曼哈顿HIV脑库（MHBB）是一个为NeuroAIDS研究提供特征良好的人体组织和液体的资源。 作为国家神经艾滋病组织联盟（NNTC）的一部分，它向广泛的调查人员分发材料，并已开始一项观察调查计划。 在接下来的5年里，我们将继续并增加提供信息，组织，并从艾滋病毒感染者的液体合格的研究人员调查艾滋病毒的发病机制，并继续招募艾滋病毒感染者进入器官捐赠计划之前，纵向神经，神经心理学和精神病学研究。 无论是单独或与其他NNTC网站，我们将研究传统的临床病理相关性的生前功能与死后病理，并检查神经艾滋病疾病的纵向进展。 我们还将在HIV阴性对照队列中创建一个器官捐赠计划，该计划将作为病毒学控制材料的来源，并有助于分析肝脏对NeuroAIDS疾病的影响。 具体而言，一组具有明确死亡风险的移植前肝病患者将被招募到器官捐赠计划和NNTC测试组合的纵向研究中。 将继续关注HIV相关CNS和PNS疾病的合并症和健康差异，特别是在定义肝病、物质障碍和HIV对认知和神经功能障碍的贡献方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Manhattan HIV Brain Bank (MHBB) is a resource that provides well-characterized human tissues and fluids for NeuroAIDS research. As part of the National NeuroAIDS Tissue Consortium (NNTC), it distributes materials to a wide range of investigators, and has begun a program of observational investigation. In the next 5 year period, we will continue and increase the provision of information, tissues, and fluids from HIV-infected patients to qualified researchers investigating HIV pathogenesis, and continue to recruit HIV-infected patients into an organ donation program preceded by a longitudinal neurologic, neuropsychologic, and psychiatric study. Both individually and with other NNTC sites, we will examine traditional clinico-pathologic correlations of premortem function with postmortem pathology, and to examine the longitudinal progression of neuroAIDS disorders. We will additionally create an organ donation program in an HIV-negative control cohort, that will serve as a source of virologic control materials and also aid in the dissection of hepatic influences on NeuroAIDS disorders. Specifically, a group of pre-transplant liver disease patients with well-defined risk of mortality will be recruited to an organ donation program and longitudinal study with the NNTC battery of tests. There will be a continued focus on co-morbidities and health disparities in HIV-related CNS and PNS disorders, particularly in defining contributions of liver disease, substance disorders, and HIV on cognitive and neurologic dysfunction.