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Anakinra for neutrophilic pustular skin disease

Anakinra for neutrophilic pustular skin disease
阿那白滞素（Anakinra）治疗中性粒细胞性脓疱性皮肤病
批准号：
10262363
负责人：
Edward Cowen
金额：
$10.93万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10262363
关键词：
BiologicalClinicalCollaborationsDiseaseEnrollmentGoalsInterleukin-1LaboratoriesOutcomePET/CT scanPathway interactionsPatientsProtocols documentationPustular psoriasisSamplingSerumTherapeuticTissuesTreatment Protocolsanakinracardiovascular disorder riskdesignneutrophilskin disorder

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中文摘要
翻译
迄今为止，已有17名患者参加了该治疗方案。25-30例患者的目标是确定阿那金对脓疱性中性粒细胞皮肤病是否有效。除临床结果外，组织和血清样本将被送往Raphaela Goldbach-Mansky、Maria Morasso、Alison McBride和Nehal Mehta的实验室，以进一步研究脓疱性银屑病的生物学途径，包括通过PET/CT评估的心血管疾病风险。
英文摘要
To date, 17 patients have enrolled on this treatment protocol. A goal of 25-30 patients has been established to determine if anakinra has efficacy for pustular neutrophilic skin disease. In addition to the clinical outcomes, tissue and serum samples are being sent to the lab of Raphaela Goldbach-Mansky, Maria Morasso, Alison McBride, and Nehal Mehta in order to further investigate the biologic pathways responsible for pustular psoriasis, including risk of cardiovascular disease as assessed by PET/CT.
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Anakinra for neutrophilic pustular skin disease
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海外基金
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data