CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

这项任务是进行核心行政活动，包括项目管理以及存储 化学和生物库存、存档文件和数据、设备维护，以及 继续在化学品筛选和优化设施（CSOF）中开展数据库维护活动 支持避孕研究分支（CRB）开发避孕药物的使命， NICHD，NIH。 CSOF通过将避孕靶点的发现和验证与研究性避孕药结合起来，发挥了独特的作用。 新药（IND）使研究和随后的临床开发和批准避孕药物。的 CSOF所需的研究将包括发现和优化小分子拮抗剂和/或 作为抗生育剂的蛋白质靶点激动剂和支持该目标的相关学科。这包括但 不限于分析开发、高通量筛选、X射线晶体学、计算化学 药物化学和药理学。该设施还将负责生产化学品 用于初步体内试验的材料。预计将执行多个独立项目 与此同时，CSO对这些项目的适当监督对它们的成功至关重要。 执行.

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The CSOF fulfills a unique role by bridging the discovery and validation of contraceptive targets to Investigational New Drug (IND) enabling studies and subsequent clinical development and approval of contraceptive drugs. The required research at the CSOF will encompass discovery and optimization of small molecule antagonists and/or agonists of protein targets as anti-fertility agents and related disciplines to support that goal. This includes, but is not limited to, assay development, high throughput screening, x-ray crystallography, computational chemistry, medicinal chemistry, and pharmacology. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.