The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants

摘要：项目3--伊索研究 爱荷华州超级基金研究计划(ISRP)伊索研究(空气中暴露于半挥发性有机物质 污染物)是一项以社区为基础的参与性研究，评估吸入和饮食暴露 青春期儿童及其母亲队列对多氯联苯、多氯联苯代谢物和潜在生物标志物的影响 在美国中西部的三个社区。我们之前报告过，尽管故意生产多氯联苯作为 遗留的超级基金化学品在20世纪70年代结束，生产继续作为建筑材料的副产品。这个 伊索研究确定了多氯联苯暴露的决定因素，包括饮食摄入量和空气暴露 室内和室外的水平。在拟议的新资金周期中，伊索研究将拥有无与伦比的 有机会确定个人在家庭和学校对多氯联苯的吸入暴露的作用 对暴露负担的贡献，可能导致荷尔蒙紊乱、代谢 综合症和神经行为结果。具体目标是：目标1：收集和分析人口统计数据， 伊索研究参与者的居住、职业、活动、饮食和健康数据。目标2：确定特征 儿童及其母亲对多氯联苯同系物的个人暴露，以及对 吸入和饮食达到同类水平。这项研究将分析血液和尿液中209种多氯联苯和74种多氯联苯 代谢物以及甲状腺激素功能障碍、炎症和代谢综合征的生物标志物。 目标3：评估青春期儿童对空气中多氯联苯的时间综合个人暴露。目标4：印刷电路板模型 相似的暴露和身体负担；比较建模数据和测量数据。这项研究深受欢迎 通过我们的社区咨询委员会与伊索研究人员和 ISRP社区参与核心；这一支持将有助于促进这些目标。《伊索研究》 雇用双语社区外勤工作人员，并已登记和跟踪381名种族和 种族多元化的社区，为空气中暴露和由此造成的身体负担提供了新的见解。 伊索研究向ISRP内的其他项目提供了人类样本和数据，提供了增强的 与这些项目的相关性。未识别的数据被广泛分享给研究参与者，科学 社区，以及EPA和ATSDR的利益攸关方。伊索研究已经改变了流行的 对大多数美国人如何接触多氯联苯的看法。我们已经证明，孩子们有大量的 在学校因吸入多氯联苯而接触到多氯联苯同系物；他们的血液显示吸入较低的 氯化的同系物。这对儿童的环境健康具有重要的影响，伊索 未来五年的研究将进一步阐明这一点。

SUMMARY: Project 3 – The AESOP Study The Iowa Superfund Research Program (ISRP) AESOP Study (Airborne Exposures to Semi-volatile Organic Pollutants) is a community-based participatory research study that assesses inhalation and dietary exposures to PCBs, PCB metabolites, and potential biomarkers among cohorts of adolescent children and their mothers in three Midwest U.S. communities. We previously reported that although intentional production of PCBs as legacy Superfund chemicals ended in the 1970s, production continues as building material byproducts. The AESOP Study identifies the determinants of PCB exposures, including dietary intake and airborne exposure levels indoors and outdoors. In the proposed new funding cycle, the AESOP Study will have an unparalleled opportunity to characterize the role of personal inhalation exposures to PCBs at home and in schools for their contribution to the exposure burden that could result in elevated risks for hormone disruption, metabolic syndrome, and neurobehavioral outcomes. The Specific Aims are: Aim 1: Collect and analyze demographic, residential, occupational, activity, dietary, and health data from AESOP Study participants. Aim 2: Characterize personal exposures to PCB congeners among children and their mothers and apportion exposures to inhalation and diet at the congener level. The study will analyze blood and urine for 209 PCBs and 74 metabolites as well as for biomarkers of thyroid hormone dysfunction, inflammation, and metabolic syndrome. Aim 3: Assess adolescent children’s time-integrated personal exposure to airborne PCBs. Aim 4: Model PCB congener exposures and body burdens; compare modeled and measured data. The study enjoys strong community support garnered through our Community Advisory Boards working with AESOP Study staff and the ISRP Community Engagement Core; this support will help facilitate these aims. The AESOP Study employs bilingual community-based field staff and has enrolled and followed 381 subjects in racially and ethnically diverse communities, providing new insights into airborne exposures and resulting body burdens. The AESOP Study provides human samples and data to other projects within the ISRP, providing enhanced relevance for those projects. De-identified data are widely shared with study participants, the scientific community, and stakeholders at EPA and ATSDR. The AESOP Study has already changed the prevailing views on how most Americans are exposed to PCBs. We have demonstrated that children have substantial exposure to PCB congeners from inhalation at school; their blood shows enrichment with inhaled lower- chlorinated congeners. This has important implications for children’s environmental health that the AESOP Study will further elucidate during the next five years.