Emotion Regulation and Sleep in Alcohol Use Disorder

项目摘要/摘要 酒精使用障碍(AUD)是一种多方面的慢性复发性障碍，数百万男性和女性都患有这种疾病 在美国。AUD与睡眠连续性和结构中断有关，包括异常 持续到禁欲的高水平快速眼动(REM)睡眠，这是一种显著的 复发的预测指标。情绪缺陷，包括情绪平台化和皮质边缘低反应性 对于情绪刺激，AUD的发现是一致的，也可以预测复发。在这里，我们带来了这两个 基于一项新兴文献，该文献表明快速眼动睡眠对神经情绪很重要 调节，校准情绪以促进第二天的适应性情绪功能。 我们认为AUD患者的快速眼动睡眠-情绪通路功能障碍，是导致情绪缺陷的原因之一。 我们和其他人所展示的对AUD的监管，这会导致渴望和复发的增加。 在这里，多学科研究人员(贝克，Műler-Oehring)结合了AUD、睡眠、功能磁共振和 情绪，目的是研究快速眼动睡眠在AUD患者第二天情绪功能中的作用。一本小说 平衡、混合措施试验设计在男性和女性AUD禁欲患者中的应用 与年龄和性别匹配的健康对照组相比，所有人都经历了两种实验性的夜间条件： 不间断睡眠和选择性快速眼动睡眠减少，每一种都伴随着情绪的功能神经成像 第二天早上完成了反应性和情绪调节任务。 我们的目标是(1)确定快速眼动睡眠质量(持续时间和强度)和第二天神经功能之间的关系 AUD的情绪反应；(2)确定第二天实验性快速眼动睡眠减少的具体效果 AUD患者的神经情绪反应性与健康对照组和不间断睡眠的比较 条件。我们还将探索睡眠-情绪调节联系在多大程度上可以通过REM睡眠进行调整 简化协议，以建立一个功能更完整的系统，有助于行为的正常化 AUD患者的情绪功能和较少的酒精渴望的测量。 这些研究为机械地理解睡眠过程和睡眠之间的联系开辟了新的途径。 AUD患者的情绪脑功能。这些发现将为旨在调查睡眠影响的R01应用程序提供信息 手法作为重置神经情绪调节回路，打破复发循环，并改善 澳元的管理。

PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) is a multifaceted, chronic relapsing disorder suffered by millions of men and women in the United States. AUD is associated with disrupted sleep continuity and architecture, including an abnormally high level of rapid eye movement (REM) sleep that persists long into abstinence, and which is a significant predictor of relapse. Emotion deficits, including affective flattening and mesocorticolimbic hypo-responsiveness to emotional stimuli, are consistent findings in AUD and also predict relapse. Here, we bring these two components together, building on an emerging literature showing that REM sleep is important for neural emotion regulation, calibrating emotions to promote next-day adaptive emotional functioning. We propose that the REM sleep-emotion pathway is dysfunctional in AUD, contributing to the deficits in emotion regulation in AUD shown by us and others, which lead to increased craving and relapse. Here, multidisciplinary researchers (Baker, Műller-Oehring) with combined expertise in AUD, sleep, fMRI, and emotion, aim to investigate the role of REM sleep in next-day emotional functioning in AUD. A novel counterbalanced, mixed-measures experimental design is applied in abstinent male and female AUD patients compared to age- and gender-matched healthy controls, all undergoing two experimental night conditions: uninterrupted sleep and selective REM sleep reduction, each followed by functional neuroimaging with emotion reactivity and emotion regulation tasks the following morning. We aim to (1) Determine relationships between REM sleep qualities (duration and intensity) and next-day neural emotional reactivity in AUD; (2) Determine specific effects of experimental REM sleep reduction on next-day neural emotional reactivity in AUD compared to healthy controls and compared to an uninterrupted sleep condition. We will also explore to what extent the sleep-emotion regulation link is adjustable with a REM sleep reduction protocol towards a more functionally-intact system that contributes to normalization of behavioral measures of emotion functioning and less alcohol craving in AUD. These studies open up new avenues into a mechanistic understanding of links between sleep processes and emotional brain function in AUD. Findings will inform a R01 application aimed at investigating the effects of sleep manipulation as a pathway to reset neural emotion regulation circuits, fracture the cycle of relapse, and improve management of AUD.