Expanding capacity of the National Swine Resource and Research Center

项目摘要 国家猪资源和研究中心（NSRRC）是美国国立卫生研究院资助的唯一一个猪资源中心。 中心开发和提供猪模型用于生物医学研究。猪共享解剖和生理 与人类的特性，使它们成为研究许多人类疾病的最佳模型，例如， 心血管疾病、视神经疾病、动脉硬化、糖尿病和特定传染病。的 猪器官的解剖学和生理学也使它们成为异种移植供体的可能候选者。 因此，猪越来越多地被用作人类疾病的模型。有了猪的基因组序列，少校 在开发猪特异性试剂和建立携带靶向抗体的猪模型方面取得了进展， 基因改造有了这些工具，猪模型正在做出前所未有的贡献， 解开人类疾病的分子基础，开发新的治疗策略。与兴趣 在猪模型方面，国家科学和技术研究委员会负责为研究项目提供猪模型， 超过十个不同的国家卫生研究院。自2006年成立以来，国家和区域委员会的活动不断增加。 另一方面，NSRRC的住房能力多年来几乎没有改善， 已扩大到无特定病原体（SPF）猪设施。限制现在阻止了 开发额外的模型或向不同的研究人员提供动物。中心不能满足 要求适当地作为猪的国家资源模型。要解决此限制并超越 美国主要的猪资源中心，我们建议增加国家减灾中心的容纳能力。我们 建议建造一座由8，420总平方英尺（GSF）的猪舍面积连接的建筑物 现有的NSRRC SPF养猪设施，以提高NSRRC的养猪能力。原施工 NSRC预计中心和基础设施（水、电和下水道）的扩建足够 为这次扩建计划安装的。利用现有的基础设施将使我们能够获得更多 在预算范围内的猪舍。此外，拟议的动物圈养区将使我们能够 最大限度地利用现有设施中的围栏，因为增加的空间将使我们能够将所有猪 在合适的系统下运行。NSRRC一直处于提供猪模型的最前沿， 生物医学界。自成立以来，我们的活动已显着扩大， 现在是我们服务生物医学界的一个关键限制。空间限制阻碍了我们 快速繁殖和建立猪模型，以满足NIH社区的需求。的 拟议的建设不仅限于增加动物的住房，但将允许更有效地利用 现有的空间，允许NSRRC探索新的猪模型在各个研究领域的应用 并扩大我们使用猪模型的培训活动。

Project Summary The National Swine Resource and Research Center (NSRRC) has been the only NIH-funded swine resource center to develop and supply swine models for biomedical research. Swine share anatomic and physiologic characteristics with humans that make them the optimal model for the study of many human diseases, e.g., cardiovascular disease, optic diseases, arteriosclerosis, diabetes, and specific infectious diseases. The anatomy and physiology of pig organs also makes them likely candidates for xenotransplantation donors. Thus, increasingly, pigs are being used as models for human disease. With a sequenced pig genome, major advances have been made in developing swine-specific reagents and creating swine models carrying targeted genetic modifications. With these tools in place, pig models are making unprecedented contributions toward unraveling the molecular basis of human disease and developing new therapeutic strategies. With the interest in swine models, the NSRRC is responsible for supplying swine models for research projects sponsored by over ten different NIH institutes. Since its foundation in 2006, activity of NSRRC has continued to increase. Housing capacity of NSRRC, on the other hand, had few improvements throughout the years and no expansion has been made to the Specific Pathogen Free (SPF) swine facility. The limitation is now preventing development of additional models or suppling animals to a diverse group of researchers. The center can’t meet the demand to properly serve as the national resource of swine models. To resolve this limitation and excel as the main swine resource center in the U.S., we propose to increase the housing capacity of NSRRC. We propose to construct a building consisting of 8,420 gross square feet (GSF) of swine housing area connected to the existing NSRRC SPF swine facility to enhance swine housing capacity of NSRRC. Original construction of the NSRRC anticipated expansion of the center and infrastructure (water, electricity, and sewer) sufficient for this proposed expansion was installed. Utilizing the existing infrastructure will allow us to acquire more swine housing space within the budget. In addition, the proposed animal housing area will enable us to maximize the use of penning in the existing facility as the enhanced space will allow us to place all swine models under a suitable penning system. The NSRRC has been at the forefront of providing swine models to the biomedical community. Our activities have been significantly expanded since inception and swine housing is now a critical limitation for us to serve the biomedical community. The space restriction hinders us from rapidly breeding and establishing swine models to accommodate demands from the NIH community. The proposed construction is not limited to just additional animal housing but will permit more efficient use of the existing space, permitting the NSRRC to explore application of new swine models in various research fields and extend our training activity on the use of swine models.