Center for Excellence in Host Pathogen Interactions

摘要 这项Cobre第二阶段申请建议继续支持联合国开发计划署东道主卓越中心- 病原菌相互作用(HPI)。该中心的长期目标是加深对东道主的了解 对导致急性和慢性炎症性疾病的病毒、细菌和寄生虫侮辱的反应。远景 该中心的目标是继续激发人们对宿主-微生物相互作用研究的兴趣，并执行范式-- 不断变化的科学支持这样一个概念，即疾病发展是 易受宿主、外来侮辱和有利的微环境。在第一阶段，这个中心取得了重要的进展 通过扩大研究传染病和炎症性疾病各个方面的调查人员人数而取得的进展 疾病(从最初的9个实验室增加到现在的18个实验室)。自2016年第一期资助以来，这一核心群体 科布雷研究人员为该领域做出了重大贡献，出版了169份出版物， 23617386美元的外部资金和74次演讲活动(当地、国家和国际)。与 第一阶段项目负责人毕业成功率80%(6名调查人员中有4名毕业于R01资助)， 该中心将通过以下方式继续促进宿主-微生物相互作用的研究：1)召集四名年轻的 研究人员以综合、协作和多学科的方式紧密合作进行研究 包括极为及时的新冠肺炎感染、肠道生物失调、食物过敏、胃肠道寄生虫等 感染，以及病毒与呼吸道上皮的相互作用；2)增强创新的研究能力 中心，支持3个现有的一期核心设施；3)建立一个新的计算数据分析核心 以满足Cobre调查人员的新要求；以及4)通过以下方式吸引新的调查人员加入集团 支持试点奖补机制。最终目标是将HPI Cobre转变为可持续的、良好的- 有组织的学术中心，将作为增加来自 不同的背景，对宿主-微生物的各个方面的研究感兴趣 互动。

Summary This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host- Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host responses to viral, bacterial and parasitic insults leading to acute and chronic inflammatory diseases. The vision of this Center is to continue to inspire interest in the study of host-microbe interaction and perform paradigm- shifting science that supports the notion that disease development is an interplay of the interaction between a susceptible host, foreign insult and conducive microenvironment. In Phase 1 this center made significant progress by expanding the number of investigators studying various aspects of infectious and inflammatory diseases (from the initial group of 9 labs to now 18 labs). Since the funding of Phase 1 in 2016, this core group of COBRE investigators has made significant contributions to the field by producing 169 publications, $23,617,386 in extramural funding, and 74 speaking engagements (local, national and international). With the project leader graduation success rate of 80% (4 out 6 investigators graduated with R01 funding) in Phase 1, this Center will continue to promote research on host-microbe interaction by: 1) bringing together four young investigators working cohesively in an integrative, collaborative, and multidisciplinary manner on research encompassing extremely timely COVID-19 infection, intestinal dysbiosis in food allergy, gastrointestinal parasitic infection, and viral interaction with respiratory epithelium; 2) enhance the innovative research capabilities of the Center by supporting 3 existing Phase 1 Core facilities; 3) establishing a new Computational Data Analysis Core to meet the emerging requirements of COBRE investigators; and 4) attract new investigators to the group by supporting pilot grant mechanisms. The ultimate goal is to transition the HPI COBRE to a sustainable, well- organized academic center which will serve as a conduit for increased interaction between investigators from diverse backgrounds with a thematic interest in pursuing research on various aspects of host-microbe interactions.