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Identifying small molecules with selective toxicity towards muscle invasive prostate cancer cells

Identifying small molecules with selective toxicity towards muscle invasive prostate cancer cells
鉴定对肌肉侵袭性前列腺癌细胞具有选择性毒性的小分子
批准号：
10916056
负责人：
Mark Henderson
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916056
关键词：
Biological AssayCell SurvivalCell modelChemicalsClinicalFollow-Up StudiesInvadedLibrariesMuscleNeoplasm MetastasisOncologyOrganPhaseResistanceSmooth MuscleToxic effectcancer cellchemotherapydrug sensitivityhigh throughput screeningnovelprostate cancer cellprostate cancer cell linesmall moleculetaxane

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中文摘要
翻译
这个项目团队的目标是筛选和开发具有不同药物敏感性特征的肌肉浸润性前列腺癌细胞系的化学探针。 在此期间，使用细胞活性分析从肿瘤学重点和临床批准的文库中筛选了10,000多种化合物，以确定相对于亲代和多样化的前列腺癌细胞模型具有致命性和特异性的针对肌肉浸润性前列腺癌细胞系的化学探针。确定并选择了几类具有不同作用机制的化合物进行后续研究。
英文摘要
This project team aims to screen and develop chemical probes with differential drug sensitivity profiles of a muscle-invasive prostate cancer cell line. During this period, more than 10,000 compounds from oncology-focused and clinically-approved libraries were screened using cell viability assays to identify chemical probes that lethally and specifically target muscle-invasive prostate cancer cell lines, relative to parental and diverse prostate cancer cell models. Several classes of compounds with distinct mechanisms of action were identified and selected for follow-up studies.
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