CTSA Postdoctoral T32 at Tufts University

项目摘要 大力支持生物医学研究培训的理由从未像现在这样强烈。在过去两年中 多年来，该国的翻译研究企业受到了大流行的压力测试，显示出两者都令人震惊 长处和惊人的短处。虽然未来生物医学和公共卫生挑战的确切性质 目前尚不清楚，很明显，国家的安全和福祉取决于强大的科学家队伍 拥有不同的专业知识，他们在整个临床和医疗领域的核心能力方面都受到了良好的培训 翻译科学(CTS)。人们越来越认识到，在狭窄的领域之外培训研究人员 科学专业化，包括一套更多样化的研究和专业技能-特别是那些 与后来的翻译阶段相关-对于实现转变人类健康和 应对新挑战。这些领域一直是塔夫茨临床和医疗中心的标志性优势 翻译科学(CTS)研究生项目是塔夫茨临床与翻译科学的培养核心 研究所(CTSI)。我们的硕士/博士项目成立于1999年，是全国第一个临床研究项目 在生物科学研究生院和学术医学中心工作，我们不断地 不断发展，以满足不断变化的CTS培训需求。我们的成功可以从我们的生产力上得到证明 受训者，毕业生在研究职业生涯中的高留存率，以及我们杰出的历史 培养临床研究领域的领军人物。这项建议的两个主要目标包括： 目标1：培养下一代早期职业研究人员的批判性思维技能和严谨 应对未来几十年翻译科学挑战的方法论。我们将提供 对临床和生物医学研究员进行CTS核心知识期望的严格培训 通过利用我们新的和长期的伙伴关系实现不同的利益；通过建立和扩大 在我们的硕士/博士研究生项目中CTS培训的卓越历史；通过加强三个专业的T32 跟踪，包括预测分析和比较有效性研究(PACER)；One Health；以及 卫生政策和健康差距(HPHD)。 目标2：使早期职业研究人员成为有效的领导者、团队成员、沟通者和 翻译科学领域的创新者。我们将丰富学生的个性化辅导和研究经验 T32学员通过利用塔夫茨CTSI和合作机构的基础设施提供补充 在利益相关者和社区参与、科学交流、团队科学、专业人员方面的培训 发展和领导力、严格性和透明度以及对研究的批判性审查；并通过策划和 利用塔夫茨CTSI和伙伴机构内的经验机会，重点是 数据科学和信息学、临床试验创新和最佳实践、创业创新。

Project Summary The case for robust support for biomedical research training has never been stronger. During the last two years, the nation’s translational research enterprise was stress tested by a pandemic, revealing both stunning strengths and startling weaknesses. While the precise nature of future biomedical and public health challenges cannot be known, it is clear that the safety and welfare of the country depends on a robust pipeline of scientists with diverse expertise, who are well trained in core competencies across the full spectrum of clinical and translational science (CTS). It is increasingly recognized that training researchers outside of their narrow field of scientific specialization, to include a more varied set of research and professional skills—particularly those related to later translational phases—is critical to deliver on the promise to transform human health and respond to new challenges. These areas have long been signature strengths of the Tufts Clinical and Translational Science (CTS) Graduate Program, the training core of Tufts Clinical and Translational Science Institute (CTSI). Our MS/PhD program was founded in 1999 as the nation’s first clinical research program based at a school of graduate biomedical sciences and an academic medical center and we have continuously evolved to meet the changing needs of CTS training. Our success is evidenced by the productivity of our trainees, the consistently high rate of retention of graduates in research careers, and our outstanding history of training leaders in clinical research. The two principal aims of this proposal include the following: AIM 1: Train the next generation of early career researchers in critical thinking skills and rigorous methodology to meet the translational science challenges of the coming decades. We will provide rigorous training in the core knowledge expectations of CTS to clinical and biomedical research fellows with diverse interests by leveraging our new and longstanding partnerships; by building and expanding upon the history of excellence in CTS training in our MS/PhD Graduate Program; by enhancing three specialized T32 Tracks, including Predictive Analytics and Comparative Effectiveness Research (PACER); One Health; and Health Policy and Health Disparities (HPHD). AIM 2: Prepare early career researchers to be effective leaders, team members, communicators, and innovators in translational science. We will enrich the individualized mentoring and research experiences of the T32 trainees by leveraging the infrastructure of Tufts CTSI and partner institutions to provide supplemental training in stakeholder and community engagement, science communication, team science, professional development and leadership, rigor and transparency, and critical review of research; and by curating and capitalizing on experiential opportunities within the Tufts CTSI and partner institutions, with an emphasis on data science and informatics, clinical trial innovation and best practices, and entrepreneurship and innovation.