Novel regulation of inflammasomes by cytokine signalling pathways in gastric disease

胃炎(胃炎)与幽门螺杆菌感染密切相关，也可发展为胃癌。然而，在很大程度上仍不清楚幽门螺杆菌是如何在人体内引发这些胃病的。利用发展胃炎和肿瘤的小鼠模型，我们的目标是确定胃中称为炎症体的蛋白质复合体在触发对幽门螺杆菌的慢性炎症反应中所起的作用，从而导致胃病。

Stomach inflammation (gastritis) is strongly associated with Helicobacter pylori bacterial infection, and can also progress to gastric cancer. However, it remains largely unknown how Helicobacter triggers these gastric diseases in people. Using a mouse model which develops gastric inflammation and tumours, our aim is to determine the role of protein complexes in the stomach called inflammasomes in triggering chronic inflammatory responses to Helicobacter that lead to gastric disease.