PROTECTIVE IMMUNITY TO ENTAMOEBA HISTOLYTICA INFECTION

本研究项目对原生动物寄生虫组织溶血杆菌进行了研究。 重点研究了猪瘟病毒表面抗原的分离和鉴定。 与宿主肠道细胞相互作用的阿米巴，在理解 对E.组织溶血性感染的免疫应答及发展重组 预防阿米巴疾病的基于抗原的疫苗。这些研究中有许多 利用了一种新型的富含丝氨酸的溶组埃希氏菌蛋白(SREHP) 阿米巴表面蛋白。SCID小鼠模型的最新进展 并对3株重组E。 研究对阿米巴感染的保护性免疫， 并开发预防阿米巴感染的疫苗。

This research program on the protozoan parasite E. histolytica has focused on the isolation and characterization of surface antigens of amebae that interact with host intestinal cells, on understanding the immune response to E. histolytical infection, and developing recombinant antigen-based vaccines to prevent amebic disease. Many of these studies have utilized the serine rich E. histolytica protein (SREHP), a novel surface protein of amebae. The recent development of a scid mouse model of amebic infection, and the cloning and expression of 3 recombinant E. histolytica antigens to study protective immunity to amebic infection, and to develop vaccines to prevent amebic infection.