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Novel single-chain antibody-targeted nanoparticles for diagnosis of vascular diseases in magnetic resonance imaging

Novel single-chain antibody-targeted nanoparticles for diagnosis of vascular diseases in magnetic resonance imaging
新型单链抗体靶向纳米颗粒用于磁共振成像诊断血管疾病
批准号:
nhmrc : 472665
负责人:
Prof Karlheinz Peter
金额:
$30.73万
依托单位国家:
澳大利亚
项目类别:
NHMRC Development Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2009-12-31

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中文摘要
翻译
该项目的目的是开发有针对性的显像剂,寻找各种心血管疾病状态的特定标记物。这些药物将为检测动脉粥样硬化和血栓事件的存在和水平提供一种方法。靶向纳米颗粒可能提供了一个独特的机会来检测早期斑块,现有斑块的脆弱性和难以诊断的血管阻塞,如肺栓塞。
英文摘要
The aim of this project is to develop targeted imaging agents that seek out specific markers for various states of cardiovascular disease. These agents would provide a method for detecting the presence and level of atherosclerosis and thrombotic events. The targeted nanoparticles may provide a unique opportunity to detect very early plaques, the vulnerability of existing plaques and difficult to diagnose vessel blockages such as pulmonary embolism.
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