Optical Biology Core

光学生物学 该中心的光学生物学核心有一个 存在于四个地点。每一个都已经作为一个 UCI光学生物学资源，但中心 资金将允许购买额外的 与中心目标有关的设备（见 预算和理由），并将提供更多的 协调使用、共享信息，以及 对更广泛的研究界的影响。四 地点是1）荧光实验室 《动力学》（LFD），导演：恩里科·格拉顿; 2）《 贝克曼激光研究所（BLI），导演：布鲁斯 特罗姆伯格; 3）光学生物学中心（OBC） 发育生物学中心，由拉里 Marsh;以及4）生物物理实验室 《机动运输》（Motor-Driven Transport，MDT），导演：Steven 恶心 每个设施都提供独特的设备， 光学检测、测量、 和空间动态过程的操纵。作为 上文关于外联的一节提到， LFD和BLI是P41资助的中心， 从事发展和传播 新技术LFD侧重于以下方面的进展： 相关光谱学和粒子跟踪。的 BLI专注于探测的新型光学方法 生物物质的组织尺度特性。在 此外，MDT集成了光学镊子，力 测量、颗粒跟踪和图像分析。 OBC并不直接负责开发新的 技术，而是提供访问和 在各种各样的生物应用培训， 共焦荧光显微镜和（例如，涉及 光转换探针、FCS、FRET等）。的 OBC还分发季度通讯， 调查人员获悉， 荧光显微镜每一个设施 拥有独特的硬件和软件 供本中心会员及其访客使用。 这一核心在教育方面也发挥着重要作用 和培训，如下一节所述。

Optical Biology. The optical biology core of the Center has a presence in four locations. Each already serves as a resource for optical biology at UCI, but Center funding will allow the purchase of additional equipment related to the aims of the Center (see budget and justification), and will provide for greater coordination of use, sharing of information, and impact on the wider research community. The four locations are 1) the Laboratory for Fluorescence Dynamics (LFD), directed by Enrico Gratton; 2) The Beckman Laser Institute (BLI), directed by Bruce Tromberg; 3) The Optical Biology Center (OBC) of the Developmental Biology Center, directed by Larry Marsh; and 4) The Laboratory for the Biophysics of Motor-Driven Transport (MDT), directed by Steven Gross. Each facility provides unique equipment and expertise for the optical detection, measurement, and manipulation of spatially-dynamic processes. As previously mentioned in the section on outreach, the LFD and BLI are P41-funded centers actively engaged in the development and dissemination of new technologies. The LFD focuses on advances in correlation spectroscopy and particle tracking. The BLI focuses on novel optical methods for probing tissue-scale properties of biological matter. In addition, the MDT integrates optical tweezers, force measurements, particle tracking and image analysis. The OBC is not directly charged with developing new technology, but rather with providing access and training in a wide variety of biological applications of confocal fluorescence microscopy and (e.g. involving photoconvertible probes, FCS, FRET, etc.). The OBC also distributes a quarterly newsletter to keep investigators informed of the latest developments in fluorescence microscopy. Each of these facilities possesses unique hardware and software available for use by the Center's members and its visitors. This core also plays an important role in education and training, as discussed in the next section.