Small Animal Imaging

项目总结(见说明)： 小动物成像共享资源为基梅尔癌症中心的研究人员提供最先进的活体分子成像能力。它是在马修·塔库尔博士的指导下于2004年4月建立的，迄今为止得到了托马斯·杰斐逊大学和放射科的支持。该资源提供非侵入性小动物成像，包括PET、SPECT、CT和光学成像。这些模式为研究癌症的病理生理学和起源提供了创新的基础研究能力和临床前转化研究能力。除了提供全面的成像服务外，该公司还拥有a)定制合成针对目标生物标记的探针；b)开发新的图像生成和分析技术；以及c)培训癌症研究人员利用分子成像的优势。该设施由三个AALAC认证的动物收容所和两名兽医工作人员提供支持。迄今为止，这一共享资源支持了15项由联邦政府资助的与肿瘤学和提高生产力有关的研究，如同行评议期刊上的若干出版物所描述的那样。该设施由七名癌症中心成员使用。

PROJECT SUMMARY (See Instructions): The Small Animal Imaging Shared Resource provides state-of-the-art in vivo molecular imaging capabilities to the investigators of the Kimmel Cancer Center. It was established under the direction of Dr. Mathew Thakur in April 2004 supported, to date, by the Thomas Jefferson University and the Department of Radiology. This resource provides non-invasive small animal imaging, with PET, SPECT, CT and optical imaging. These modalities offer innovative basic, as well as pre-clinical translational, research capabilities for studying patho-physiology and genesis of cancer. In addition to providing comprehensive imaging services the expertise exists to a) custom synthesize probes specific for targeted bio-markers; b) develop new image generation and analysis techniques; and c) train cancer investigators to harness the strengths of molecular imaging. The facility is supported by three AALAC accredited animal houses and two veterinarian staff members. Thus far this shared resource has supported fifteen federally funded investigations related to oncology and enhanced productivity as depicted by several publications in peer-reviewed journals. The facility was used by seven cancer center members.