Total Synthesis of Bioactive Natural Products

描述（由申请人提供）：本计划的目标是开发合成苯乙烯化吲哚生物碱家族生物活性分子的新策略。我们构建的复杂天然产物，以及它们独特的衍生物，只有通过我们的策略才能获得，将提供小分子，作为识别通过新机制起作用的抗癌化合物的起点。我们的合成研究也应该导致深入了解一个亚群的苯乙烯化吲哚生物碱的生物合成

DESCRIPTION (provided by applicant): The goal of this program is to develop new strategies for the synthesis of bioactive molecules in the prenylated indole alkaloid family. The complex natural products that we construct, and their unique derivatives which are only accessible using our strategies, will provide small molecules that will serve as a starting point to identify anticancer compounds that function via novel mechanisms. Our synthetic studies should also lead to insights into the biosynthesis of a subset of the prenylated indole alkaloids for which the biogenesis is not established. Specifically, we intend to develop strategies to synthesize different structural classes of prenylated indole alkaloids including the citrinalins, cyclopiamine, citrinadins and the stephacidins.