Preclinical Development of Complement C5aR Antagonists for the Treatment of Motor Neuron Disease

运动神经元疾病（MND）无法治愈，每天有2名澳大利亚人死亡。炎症的改变是减缓MND的一种潜在手段。我们的研究小组已经确定了一系列新的强效抗炎化合物，可能有潜力治疗这种疾病。我们的项目将在MND动物模型中测试这些化合物，并验证它们在人类MND样品中的有用性。最终，这项工作可能有助于发现MND的新治疗方法。

There is no cure for Motor Neuron Disease (MND) resulting in 2 Australian’s dying each day. Modification of the inflammation is one potential means of slowing MND. Our research team has identified a new series of potent anti-inflammatory compounds that may have potential to treat this disease. Our project will test these compounds in animal models of MND, and validate their usefulness in human MND samples. Ultimately, this work may contribute to the discovery of a new treatment for MND.