The identification and characterisation of a new DNA receptor
The identification and characterisation of a new DNA receptor
批准号:
nhmrc : 1060522
负责人:
A/Pr Irina Caminschi
金额:
$43.78万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
免疫系统的进化是为了对抗致病微生物。首先,它必须认识到一种传染性病原体已经入侵。为了做到这一点,我们开发了许多能够感知微生物产品的探测器(受体)。检测微生物DNA是一个重要的警钟。然而,区分病原体DNA和我们自己的DNA是困难的,因为两者看起来很相似。我们已经确定了一种新的受体,它可以帮助我们识别细菌DNA,并提醒免疫系统注意迫在眉睫的危险。
英文摘要
The immune system has evolved to fight disease-causing microbes. First, it has to recognize that an infectious agent has invaded. To do this we have developed many probes (receptors) that sense microbial products. Detecting microbial DNA is a critical alarm bell. However, distinguishing pathogen DNA from our own DNA is difficult because both look alike. We have identified a new receptor that helps us identify bacterial DNA and alerts the immune system to the imminent danger.
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会议论文
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依托单位:
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依托单位:
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依托单位:
海外基金