Chemical biology investigation of cell death processes: development of molecular probes interfering with necroptosis

死亡性程序性细胞死亡在维持健康组织中起着关键作用，而这一过程的失调与感染和一系列慢性炎症性疾病的病理有关，这些疾病几乎没有令人满意的治疗方法。在这个项目中，我们将发现干扰坏死性下垂途径的小的、类似药物的分子。这些小分子有可能成为治疗这些炎症性疾病的新疗法，并将成为研究这一关键生物途径的宝贵探针。

Necroptotic programmed cell death has a key role in maintaining healthy tissue, and dysregulation of this process is associated with the pathology of infection and a range of chronic inflammation diseases for which there are few satisfactory treatments. In this project, we will discover small, drug like, molecules that interfere with the necroptosis pathway. These small molecules have the potential to become new therapeutics to treat these inflammatory diseases and will be invaluable probes to study this key biological pathway.