Structural basis of influenza A virus-specific CD8+ T cell Receptor Diversity

病毒感染导致介导病毒感染细胞清除的病毒特异性T细胞的活化和增殖。通过呈递与主要组织相容性复合体（MHC）I类糖蛋白复合的肽片段来介导病毒感染细胞的识别。病毒特异性T细胞通过在T细胞表面表达的特异性受体识别这些病毒蛋白片段。该提案计划研究决定流感特异性T细胞受体识别的结构因素。从这些研究中，我们计划确定这些结构因子如何影响病毒感染后产生的病毒特异性T细胞的多样性。这些研究的结论将使我们能够确定为什么一些病毒特异性T细胞反应是不多样的，以及病毒特异性T细胞免疫的后果是什么。这对开发旨在诱导针对病毒和肿瘤挑战的免疫力的新型疫苗策略具有影响。

Viral infection results in the activation and proliferation of virus-specific T cells that mediate clearance of virally infected cells. Recognition of virally infected cells is meditated by presentation of peptide fragments complexed to Major histocompatibility complex (MHC) class I glycoproteins. Virus-specific T cells recognise these viral protein fragments via a specific receptor expressed at the T cell surface. This proposal plans to examine the structural factors that determine influenza-specific T cell receptor recognition. From these studies, we plan to determine how these structural factors can influence the diversity of virus-specific T cells that are generated after viral infection. The conclusions from these studies will enable us to determine why some virus-specific T cell responses are not diverse and what are the consequences for virus-specific T cell immunity. This has implications for the development of novel vaccine strategies designed to induce immunity against both viral and tumour challenge.