Engineering Biomaterials to Prevent Bacterial Infections

9410429 Bryers这个项目正在研究开发生物材料，以防止细菌细胞粘附并随后生长到这些材料上。本研究的四个具体目标包括：(1)表面涂层的聚氨酯基材的制备和表征，用于抗生素和抗胶粘剂的控释；(2)在聚氨酯表面等离子沉积乙二醇低聚物制备交替表面涂覆技术；(3)细菌粘附新材料表面的动力学研究；(4)检查血小板存在时细菌附着的速率和机制。本研究结果可能对医疗植入物的细菌感染预防产生影响。＊＊＊

9410429 Bryers This project is on research to develop biomaterials that prevent the adhesion and subsequent growth of bacterial cells to these materials. The four specific aims of this research include: (1) the preparation and characterization of polyurethane substrata with surface coatings for the controlled release of antibiotics and antiadhesives; (2) the preparation of an alternate surface coating technique by plasma deposition of ethylene glycol oligomers at the polyurethane surface; (3) a study of the kinetics of bacterial adhesion to the newly created material surfaces; and (4) an examination of the rates and mechanisms of bacterial attachment in the presence of blood platelets. The results of this research could have impact on the prevention of bacterial infections for medical implants. ***