Engineering Biomaterials to Prevent Bacterial Infections

9410429 Bryers这个项目是研究开发生物材料，防止细菌细胞粘附和随后的生长到这些材料。 本研究的四个具体目标包括：（1）制备和表征具有表面涂层的聚氨酯基质以控制抗生素和抗粘连剂的释放：（2）通过在聚氨酯表面等离子体沉积乙二醇低聚物制备替代表面涂层技术;（3）研究细菌粘附到新产生的材料表面的动力学;和（4）检查在血小板存在下细菌粘附的速率和机制。 这项研究的结果可能会对预防医疗植入物的细菌感染产生影响。 ***

9410429 Bryers This project is on research to develop biomaterials that prevent the adhesion and subsequent growth of bacterial cells to these materials. The four specific aims of this research include: (1) the preparation and characterization of polyurethane substrata with surface coatings for the controlled release of antibiotics and antiadhesives; (2) the preparation of an alternate surface coating technique by plasma deposition of ethylene glycol oligomers at the polyurethane surface; (3) a study of the kinetics of bacterial adhesion to the newly created material surfaces; and (4) an examination of the rates and mechanisms of bacterial attachment in the presence of blood platelets. The results of this research could have impact on the prevention of bacterial infections for medical implants. ***