Engineering Biomaterials to Prevent Bacterial Infections

工程生物材料预防细菌感染

• 批准号: 9410429
• 负责人: James Bryers
• 金额: $ 36.14万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-10-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410429&HistoricalAwards=false
• 关键词: Engineering; Biomaterials; Prevent; Bacterial; Infections

9410429 Bryers This project is on research to develop biomaterials that prevent the adhesion and subsequent growth of bacterial cells to these materials. The four specific aims of this research include: (1) the preparation and characterization of polyurethane substrata with surface coatings for the controlled release of antibiotics and antiadhesives; (2) the preparation of an alternate surface coating technique by plasma deposition of ethylene glycol oligomers at the polyurethane surface; (3) a study of the kinetics of bacterial adhesion to the newly created material surfaces; and (4) an examination of the rates and mechanisms of bacterial attachment in the presence of blood platelets. The results of this research could have impact on the prevention of bacterial infections for medical implants. ***

9410429 Bryers这个项目正在研究开发生物材料，以防止细菌细胞在这些材料上黏附和随后生长。这项研究的四个具体目标包括：(1)表面涂层的制备和表征，用于控制抗生素和抗粘剂的释放；(2)通过等离子体沉积乙二醇齐聚体在聚氨酯表面制备替代表面涂层技术；(3)细菌在新材料表面的黏附动力学研究；(4)在血小板存在的情况下细菌黏附的速率和机制的研究。这项研究的结果可能会对预防医疗植入物的细菌感染产生影响。***