Acquisition of a 500 MHz Triple-Resonance NMR Spectrometer

德克萨斯大学奥斯汀分校请求国家科学基金会的学术研究基础设施计划提供资金，用于购买500 MHz三重共振NMR光谱仪。 拟议中的仪器将致力于生物物理研究与国家的最先进的核磁共振数据收集的要求，并将大大加强八个主要用户的研究。 拟议的文书将大大加强以下研究领域： 1. RNA和蛋白质结构2.共价修饰DNA的抗生素的作用，以及DNA-药物相互作用3.生物活性多糖和肽的结构4.代谢途径分析5.肌原纤维蛋白的结构6. RNA和DNA切割剂的结构7.烃类的酶促降解8.基因工程肽的研究

The University of Texas at Austin requests funds from the Academic Research Infrastructure Program of the National Science Foundation for the purchase of a 500 MHz triple resonance NMR spectrometer. The proposed instrument will be dedicated to biophysical research with state-of-the-art NMR data collection requirements, and will greatly enhance the research of eight major users. The proposed instrument will significantly enhance the following areas of research: 1. RNA and protein structure 2. Effects of antibiotics that covalently modify DNA, and DNA-drug interactions 3. Structure of biologically active polysaccharides and peptides 4. Analysis of metabolic pathways 5. Structure of myofibrillar proteins 6. Structure of RNA and DNA cleavage agents 7. Enzymatic degradation of hydrocarbons 8. Studies of genetically engineered peptides