NIRT: Highly Integrated Optical Nanoparticle-Based Sensing Systems Based on Nanoparticle Synthesis, Assembly, and Integration

NIRT：基于纳米颗粒合成、组装和集成的高度集成光学纳米颗粒传感系统

• 批准号: 0403912
• 负责人: April Brown
• 金额: $ 140万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0403912&HistoricalAwards=false
• 关键词: NIRT; Highly; Integrated; Optical; Nanoparticle

NIRT: Highly Integrated Optical Nanoparticle-Based Sensing Systems Project SummaryThis NIRT focuses on significant improvements in the performance and portability of sensor systems through the exploitation of nanoscale materials. This comprehensive approach relies on the team composed of chemists, electrical engineers, biomedical engineers, materials scientists and chemical engineers from Duke University, Wayne State University and the University of Wisconsin-Madison. The intellectual merit of the proposed activity results from the scientific and engineering exploration and discovery underlying the design and fabrication of a system-on-a-chip sensing system exploiting nanostructured materials as both multi-spectral emitters and robust targeted probes. Nanoparticles are increasingly important for sensing and offer a range of optical modalities. Optical signals from nanoparticles are often significantly enhanced over bulk materials allowing for miniaturization of the entire sensing system. Nanoparticles will be used in different functions: as light emitters to enable sensing and as molecular beacons to enhance signals generated during sensing. The efficacy of this integrated approach will be studied the use of these sensing\detection media to recognize tagged molecular and endogenous fluorescence targets. The sensor platform exploits new nanostructure sensing and emitting media, optical emitter structures, new means of materials integration, and demonstrates the improvements in performance gained from on-chip integration. The broader impacts of this project derive from the diversity, both disciplinary and demographic, of the team, and the inclusion of undergraduate students in the project through linkages with diversity programs. Educational articles and curricular materials will be generated such as articles in educational journals that use research results and local expertise to communicate new concepts in sensing.

NIRT：基于高度集成的光学纳米颗粒传感系统项目摘要Thistary Thirt侧重于通过剥削纳米级材料的传感器系统性能和可移植性的显着提高。这种全面的方法取决于由化学家，电气工程师，生物医学工程师，材料科学家和化学工程师组成的团队，来自杜克大学，韦恩州立大学和威斯康星大学 - 麦迪逊分校。拟议活动的智力优点是由科学和工程探索和发现的基础，即在芯片上的系统接触系统的设计和制造基础，这些系统利用了纳米结构材料，作为多光谱发射器和强大的靶向探针。纳米颗粒对于感测越来越重要，并提供了一系列光学方式。来自纳米颗粒的光学信号通常在散装材料上显着增强，从而可以使整个感应系统进行微型化。纳米颗粒将用于不同的功能：作为光发射器启用传感，并用作分子信标，以增强传感过程中产生的信号。 将研究这种综合方法的功效，使用这些传感\检测介质识别标记的分子和内源性荧光靶标。 传感器平台利用了新的纳米结构感测和发射介质，光学发射极结构，新的材料集成方式，并证明了从芯片上积分获得的性能的改善。该项目的更广泛影响来自团队的多样性，包括纪律和人口，以及通过与多样性计划的联系将本科生纳入该项目。将生成教育文章和课程材料，例如使用研究结果的教育期刊中的文章和当地专业知识来传达新的感应概念。