MRI: Acquisition of a 500 MHz NMR Spectrometer at Jackson State University

MRI：在杰克逊州立大学购买 500 MHz NMR 波谱仪

• 批准号: 0821357
• 负责人: Hongtao Yu
• 金额: $ 56.3万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821357&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; NMR

With this award from the Major Research Instrumentation program (MRI), Hongtao Yu and colleagues Kenneth Lee and Eric Noe from Jackson State University will acquire a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The requested instrument will be used to upgrade the NMR Core Facility at Jackson State University. The new spectrometer will be especially suited for high sensitivity, higher resolution structural analysis of samples produced in small quantities such as metabolites or photoproducts, low temperature studies, and complex natural product derivatives. Specific research projects that will utilize this spectrometer are: (1) structure characterization of microgram amounts of chemicals from light or chemical degradation, light-induced DNA adducts, and metabolites; (2) characterization of relatively complex natural products and their analogues; (4) characterization and kinetic study of organometallic compounds and macromolecules for anion recognition; (4) low temperature conformational studies of organic compounds; (5) structural assignment for synthetic organic compounds and intermediates.Nuclear Magnetic Resonance spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry.

凭借这项来自重大研究仪器计划（MRI）的奖项，来自杰克逊州立大学的Hongtao Yu和同事Kenneth Lee和Eric Noe将获得一台500 MHz核磁共振（NMR）光谱仪。所要求的仪器将用于升级杰克逊州立大学的核磁共振核心设施。 新的光谱仪将特别适合于高灵敏度，更高分辨率的结构分析，如代谢物或光产物，低温研究和复杂的天然产物衍生物的小批量生产的样品。 利用该光谱仪的具体研究项目有：（1）光或化学降解、光诱导DNA加合物和代谢物的微克量化学品的结构表征;（2）相对复杂的天然产物及其类似物的表征;（4）用于阴离子识别的有机金属化合物和大分子的表征和动力学研究;（4）有机化合物的低温构象研究;（5）合成有机化合物和中间体的结构归属核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学和生物化学产生影响。