MRI: Development of a Holographic Fabrication and Characterization Instrument for Materials Research and Educational Outreach

MRI：开发用于材料研究和教育推广的全息制造和表征仪器

• 批准号: 0922680
• 负责人: David Grier
• 金额: $ 76.78万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922680&HistoricalAwards=false
• 关键词: MRI; Development; Holographic; Fabrication; Characterization

0922680GrierNew York U."This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Technical Summary: This proposal requests support to develop an integrated all-optical instrument for characterizing fluid-borne objects such as colloidal particles, nanowires and biological cells, and for assembling them into three dimensional structures for applications in materials science and engineering. The instrument is based on two complementary techniques that were developed in the Principal Investigator's laboratory: quantitative holographic video microscopy, and dynamic holographic trapping. The former can track hundreds of moving objects simultaneously with nanometer resolution in three dimensions, while simultaneously measuring their dimensions and optical properties. The latter can trap hundreds of microscopic objects independently and organize them into any specified three-dimensional structure. Together, these core technologies provide unprecedented control over the microscopic world. Optimized optical and mechanical design will enable the proposed instrument to characterize and process materials that are too sensitive or too challenging for existing proof-of-concept instruments. Consequently, it will have immediate applications for rapid prototyping of soft-matter-based photonic, electronic and optical electronic devices, and also will be used for micromechanical assays of bacterial biofilms. Its accessible layout and anticipated ease of use also will facilitate rapid adoption for fundamental research in physics and biophysics. The proposed instrument will be developed and operated out of New York University?s Center for Soft Matter Research, and will serve as a core facility for NYU?s recently inaugurated Materials Research Science and Engineering Center. Its open and modular design and robust computer-driven interface will be ideal for hands-on demonstrations during regularly scheduled K-12 classroom visits to the CSMR laboratories, and will be featured in the award-winning Scientific Frontiers educational outreach program at NYU.Non-Technical Summary: Assembling microscopic building blocks into three-dimensional functional structures is one of the outstanding challenges of materials science. Picking the right objects out of chemically synthesized mixtures, putting them together, and verifying the outcome has been all but impossible. The proposed instrument addresses the assembly problem by using forces exerted by computer-generated holograms to arrange microscopic fluid-borne objects into any specified three-dimensional configuration. It complements this holographic optical trapping capability with video-rate holographic imaging to track the objects? motions in three dimensions and simultaneously to measure their physical properties, thereby solving the selection and verification problems. Together, holographic micromanipulation and holographic characterization make it possible to build up complex three-dimensional structures from chemically-synthesized components. Immediate applications include assembling optically active colloidal spheres into artificial opals with optically-switchable optical properties, building three-dimensional circuits out of chemically grown nanowires, and crafting microscopic lasers out of colloidal components. The same instrument also will used to study the micromechanical properties of bacterial biofilms. The proposed instrument?s unique combination of capabilities will provide a core facility for New York University?s recently awarded Materials Research Science and Engineering Center. It also will take center stage in NYU?s award-winning Scientific Frontiers Program, which annually hosts hands-on laboratory tours for hundreds of New York City K-12 schoolchildren. The instrument?s open design, real-time visual feedback and robust computer-driven interface will encourage students of all ages to reach into the microscopic world and explore.

0922680GrierNew York U.“该奖项是根据2009年的《美国回收与再投资法》（公法111-5）资助的。该仪器基于主要研究者实验室中开发的两种互补技术：定量全息视频显微镜和动态全息捕获。 前者可以在三个维度的纳米分辨率同时跟踪数百个移动对象，同时测量其尺寸和光学特性。后者可以独立捕获数百个显微镜对象，并将其组织成任何指定的三维结构。这些核心技术共同提供了对微观世界的前所未有的控制。 优化的光学和机械设计将使所提出的仪器能够表征和处理对现有概念验证仪器过于敏感或过于挑战的材料。 因此，它将立即应用基于软性的光子，电子和光学电子设备的快速原型，并将用于细菌生物膜的微机械测定。它可访问的布局和预期的易用性也将有助于快速采用物理和生物物理学基础研究。 拟议的工具将在纽约大学软件研究中心开发和运行，并将成为纽约大学最近开幕材料研究科学与工程中心的核心设施。 它的开放和模块化设计和强大的计算机驱动界面将是在定期安排的K-12课堂访问中对CSMR实验室进行的动手演示的理想选择，并将在NYU.NON-CEchnical摘要的屡获殊荣的科学教育外展计划中展出：组建微型构建基础：将微型的建筑块组装成三个型结构的构造构造构造的构造构成了一个出色的构图。从化学合成的混合物中挑选出正确的物体，将它们放在一起并验证结果几乎是不可能的。 提出的仪器通过使用计算机生成的全息图施加的力来解决组装问题，以将微观流体传播物体排列到任何指定的三维配置中。 它通过视频速率全息成像来补充这种全息光学诱捕能力以跟踪对象？在三个维度中的运动并同时测量其物理特性，从而解决了选择和验证问题。共同的全息显微镜和全息表征使从化学合成的成分建立复杂的三维结构成为可能。 直接应用包括将光学活跃的胶体球组装到具有光学切换的光学特性的人造蛋白石中，从化学生长的纳米线中构建了三维电路，以及从胶体组件中制作显微镜激光。 同一仪器还将用于研究细菌生物膜的微机械特性。 拟议的工具的独特功能组合将为纽约大学最近授予材料研究科学与工程中心提供核心设施。它还将在纽约大学屡获殊荣的科学领域计划中进行中心舞台，该计划每年为数百个纽约市K-12学童举办动手实验室旅行。 乐器的开放设计，实时视觉反馈和强大的计算机驱动界面将鼓励各个年龄段的学生进入微观世界并进行探索。

项目成果

In-line holographic microscopy with model-based analysis

• DOI: 10.1038/s43586-022-00165-z
• 发表时间: 2022-10-20
• 期刊: NATURE REVIEWS METHODS PRIMERS
• 作者: Martin, Caroline;Altman, Lauren E.;Manoharan, Vinothan N.
• 通讯作者: Manoharan, Vinothan N.