In-Line Label-Free Fluid Diagnostics using Photonic Resonators

使用光子谐振器的在线无标记流体诊断。布莱恩·T伊利诺伊大学厄巴纳-香槟分校电气与计算机工程系的目标是将两种新型的基于光子学的无标记检测模式集成到塑料管的内表面。 第一种检测方法是基于塑料的分布式反馈激光生物传感器，其能够对诸如疾病生物标志物和细菌病原体的分析物进行高灵敏度的基于亲和力的检测。第二种检测方法是利用光子晶体表面的共振电场来提高表面增强拉曼光谱的检测灵敏度，该方法是开发一种有源光子谐振器，该有源光子谐振器产生其自身的窄带光输出，该窄带光输出对于耦合到其激发源没有严格的对准要求，从而巧妙地解决了目前抑制高Q因子无源谐振器生物传感器在弯曲表面（例如医用管道）上实现的重要问题。光子晶体表面增强的拉曼方法将使检测灵敏度增加30- 50倍，从而能够在比目前可能的更低浓度、更短的积分时间和更低的激光功率下检测分析物。将进行与静脉输注药物输送、导尿管代谢物监测和静脉管路中早期细菌病原体检测相关的应用演示。本项目中描述的能力的发展将对医院中使用无菌塑料管进行药物输送和导尿的广泛临床治疗的患者护理产生深远的影响。该提案描述了一项教育计划，该计划对研究生研究，本科生研究，本科生课堂/实验室学习以及向一所以大学为基础的全女子中学教授生物传感/光子学概念产生影响。

In-Line Label-Free Fluid Diagnostics using Photonic ResonatorsProf. Brian T. CunninghamUniversity of Illinois at Urbana-ChampaignDepartment of Electrical and Computer EngineeringThe objective is to integrate two novel photonics-based label-free detection modalities into the internal surface of plastic tubing. The first detection method is a plastic-based distributed feedback laser biosensor that is capable of high sensitivity affinity-based detection of analytes such as disease biomarkers and bacterial pathogens. The second detection method utilizes the resonant electric fields of a photonic crystal surface to enhance the detection sensitivity of surface enhanced Raman spectroscopy.The approach is to develop an active photonic resonator that generates its own narrowband light output that has no stringent alignment requirements for coupling to its excitation source, and thus elegantly solves an important problem that currently inhibits high Q-factor passive resonator biosensors from implementation upon curved surfaces such as medical tubing. The photonic crystal surface-enhaced Raman approach will increase detection sensitivity by an additional factor of 30-50x, enabling detection of analytes at lower concentrations, shorter integration times, and lower laser power than is currently possible. Demonstration for applications relevant for infused intravenous drug delivery, urinary catheter metabolite monitoring, and early bacterial pathogen detection in intravenous lines will be performed.Development of the capabilities described in this project will have far-reaching implications for patient care in hospitals for a broad range of clinical treatments that utilize sterile plastic tubing for drug delivery and urinary catheterization. The proposal describes an education plan with impact upon graduate student research, undergraduate research, undergraduate classroom/laboratory learning, and teaching biosensing/photonics concepts to a University-based all-girls middle school.