MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance NMR Capabilities at a Major Urban Research Institution

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，威斯康星大学密尔沃基分校的Peter GeisSinger教授及其同事Graham Moran、arcio Pacheco、DeYang Qu和Nicholas Silvaggi获得了一台500 MHz核磁共振(NMR)光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及对生物相关物种的研究。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。这些核磁共振研究的结果对合成有机/无机化学、材料化学和生物化学都有影响。该仪器位于一个由高素质科学家管理的通用用户设备，是化学和生物化学系研究、研究培训和教学的组成部分。该光谱仪通过为学生提供核磁共振知识，帮助他们在许多行业(化学、制药、生物技术、工程、环境和其他)、政府机构和实验室、教育和研究机构的化学/工程工作人员中取得成功。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)酶机制；(B)非蛋白氨基酸L-内尿酸；(C)参与氨和亚硝酸盐相互转化的多种血红素呼吸酶；(D)对映体和立体专一性方法合成抗疟疾和抗利什曼双吲哚生物碱；(E)有机合成的不对称催化剂；(F)维生素D受体调节剂；(G)DNA的反应性和功能及其在DNA序列检测和药物发现中的应用；(H)能源技术和(I)用于分离金属离子的试剂、介质和方法。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Peter Geissinger from the University of Wisconsin-Milwaukee and colleagues Graham Moran, Arsenio Pacheco, Deyang Qu and Nicholas Silvaggi have acquired a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is located a general user facility managed by highly qualified scientists is an integral part of research, research training and teaching in the Departments of Chemistry and Biochemistry. The spectrometer helps in the overall mission by providing students with NMR knowledge and enable their success in the chemical/engineering workforce for many industries (chemical, pharmaceutical, biotechnological, engineering, environmental and others), government agencies and laboratories, educational and research institutions.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) enzyme mechanisms; (b) non-proteinogenic amino acid L-enduracididine; (c) multi-heme respiratory enzymes involved in the interconversion of ammonia and nitrite; (d) enantio- and stereospecific methods to synthesize antimalarial and antileishmanial bisindole alkaloids; (e) asymmetric catalysts for organic synthesis; (f) vitamin D receptor modulators; (g) reactivity and function of DNA and its application for DNA sequence detection and drug discovery; (h) energy technologies and (i) reagents, media, and processes for the separation of metal ions.