MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance NMR Capabilities at a Major Urban Research Institution

MRI：采购 500 MHz 核磁共振 (NMR) 波谱仪，以增强主要城市研究机构的 NMR 能力

• 批准号: 1625735
• 负责人: Peter Geissinger
• 金额: $ 39.27万
• 依托单位: University of Wisconsin-Milwaukee
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1625735&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; Nuclear

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Peter Geissinger from the University of Wisconsin-Milwaukee and colleagues Graham Moran, Arsenio Pacheco, Deyang Qu and Nicholas Silvaggi have acquired a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is located a general user facility managed by highly qualified scientists is an integral part of research, research training and teaching in the Departments of Chemistry and Biochemistry. The spectrometer helps in the overall mission by providing students with NMR knowledge and enable their success in the chemical/engineering workforce for many industries (chemical, pharmaceutical, biotechnological, engineering, environmental and others), government agencies and laboratories, educational and research institutions.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) enzyme mechanisms; (b) non-proteinogenic amino acid L-enduracididine; (c) multi-heme respiratory enzymes involved in the interconversion of ammonia and nitrite; (d) enantio- and stereospecific methods to synthesize antimalarial and antileishmanial bisindole alkaloids; (e) asymmetric catalysts for organic synthesis; (f) vitamin D receptor modulators; (g) reactivity and function of DNA and its application for DNA sequence detection and drug discovery; (h) energy technologies and (i) reagents, media, and processes for the separation of metal ions.

在主要研究仪器计划（MRI）的奖励和化学研究仪器计划（CRIF）的支持下，威斯康星大学密尔沃基分校的Peter Geissinger教授及其同事Graham Moran，Arsenio帕切科，Deyang Qu和Nicholas Silvaggi获得了500 MHz核磁共振（NMR）光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及生物相关物种的研究。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。这些NMR研究的结果对合成有机/无机化学、材料化学和生物化学产生了影响。该仪器位于由高素质科学家管理的一般用户设施，是化学和生物化学系研究，研究培训和教学的组成部分。光谱仪通过为学生提供NMR知识，帮助他们完成整体使命，并使他们在许多行业的化学/工程劳动力中取得成功（化学、制药、生物技术、工程、环境和其他）、政府机构和实验室、教育和研究机构。该奖项旨在加强各级的研究和教育，特别是在以下领域：（a）酶机制;（B）非蛋白原性氨基酸L-精氨酸;（c）参与氨和亚硝酸盐相互转化的多血红素呼吸酶;（d）合成抗疟疾和抗利什曼双吲哚生物碱的对映和立体特异性方法;（e）有机合成的不对称催化剂;（f）维生素D受体调节剂;（g）DNA的反应性和功能及其在DNA序列检测和药物发现中的应用;（h）能源技术和（i）用于分离金属离子的试剂、介质和工艺。