ISS: Plasmonic Bubble Enabled Nanoparticle Deposition under Micro-Gravity

ISS：微重力下等离子气泡实现纳米颗粒沉积

• 批准号: 2224307
• 负责人: Tengfei Luo
• 金额: $ 72.62万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2224307&HistoricalAwards=false
• 关键词: ISS; Plasmonic; Bubble; Enabled; Nanoparticle

Novel technologies that are simple and cost-effective for fabricating highly sensitive biosensors may significantly benefit a wide range of important applications, such as early detection of epidemic/pandemic infectious disease, cancers, and other biological agents. A major challenge for such detection is the low concentration of the target molecules. This project will leverage the fluid flow around a thermal bubble on a surface, concentrating and depositing the target molecules in the liquid sample, to enhance their detectability. The PI will perform microgravity experiments at the International Space Station to investigate the concentration/deposition processes, which will enable the development of improved sensing techniques for disease detection, cancer diagnosis and environmental monitoring. Given the potential transformative impacts for terrestrial applications, this project is aligned with the mission of CASIS to leverage space research to benefit life on earth. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project. This project aims to understand the flow phenomena around a thermal bubble generated on a surface by a laser excitation. The flow pattern around the bubble can collect and eventually deposit colloidal particles in the liquid onto the surface. The overarching goal of this project is to understand the flow and deposition mechanism in order to control the deposition of suspended particles and thus enable new technologies for sensing applications. The PI will combine the microgravity experiments in the ISS and comparative terrestrial experiments complemented by multi-physics modeling to achieve this understanding. The micro-gravity environment in the ISS will provide a unique platform to unlock the fundamental mechanism of bubble nucleation, growth, and detachment. The lack of thermal convection in the ISS will allow the decoupling of the contribution of Marangoni effect from thermal convection effect to elucidate their roles in collecting colloidal particles and depositing them on the surface. This research will improve the understanding of the fundamental opto-thermal-fluidic mechanism of the thermal bubble deposition process, which will contribute to advancing the fields of nanoscale interactions, thermofluids and biosensing. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

制造高灵敏度生物传感器的新技术简单且成本效益高，可能大大有利于广泛的重要应用，如流行病/大流行性传染病、癌症和其他生物制剂的早期检测。这种检测的一个主要挑战是目标分子的低浓度。该项目将利用表面热泡周围的流体流动，浓缩和沉积液体样品中的目标分子，以提高它们的可探测性。PI将在国际空间站进行微重力实验，以调查浓缩/沉积过程，这将使改进的传感技术得以开发，用于疾病检测、癌症诊断和环境监测。考虑到对陆地应用的潜在变革性影响，该项目与CASIS利用空间研究造福地球生命的使命保持一致。这一研究项目还将教育和培训巴黎圣母院代表不足群体的研究生和本科生。通过这个项目，PI将为美国制造业和医疗保健行业培养未来的劳动力。国际和平协会还将与当地高中进行接触，并参加当地的科学活动，以扩大该项目的范围。本项目旨在了解激光激励表面产生的热泡周围的流动现象。气泡周围的流动模式可以收集液体中的胶体颗粒，并最终将其沉积到表面。该项目的首要目标是了解流动和沉积机制，以便控制悬浮颗粒的沉积，从而使新的传感应用技术成为可能。PI将结合国际空间站的微重力实验和地面比较实验，并辅之以多物理建模，以实现这一理解。国际空间站的微重力环境将为解开气泡成核、生长和脱离的基本机制提供一个独特的平台。国际空间站中没有热对流，这将使Marangoni效应的贡献与热对流效应脱钩，以阐明它们在收集胶体颗粒并将其沉积在表面上的作用。这一研究将加深对热泡沉积过程基本光热流体机理的理解，有助于推动纳米尺度相互作用、热流体和生物传感等领域的发展。这一研究项目还将教育和培训巴黎圣母院代表不足群体的研究生和本科生。通过这个项目，PI将为美国制造业和医疗保健行业培养未来的劳动力。PI还将与当地高中进行接触，并参加当地的科学活动，以扩大该项目的范围。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Analytical model of optical force on supercavitating plasmonic nanoparticles

超空泡等离子体纳米颗粒的光学力分析模型

• DOI: 10.1364/oe.491699
• 发表时间: 2023
• 期刊: Optics Express
• 影响因子: 3.8
• 作者: Mandal, Amartya;Lee, Eungkyu;Luo, Tengfei
• 通讯作者: Luo, Tengfei