Analysis of gastorintestinal problems in autism mouse models

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Autism is a highly prevalent neurological disorder characterized by impaired social interactions and stereotyped or repetitive behaviours. Autism-associated GI symptoms frequently present from early childhood to adulthood and patients with autism are approximately four-fold more likely to be hospitalized with GI disorders. GI function is regulated by the intrinsic enteric nervous system (ENS), a complex network of neurons extending along the length of the GI tract arranged in two plexuses, the submucosal and myenteric plexuses that predominantly regulate gut secretion and motility, respectively. We will characterize the GI phenotype in two preclinical models of autism (CHD8 and 15q mice) in order to identify therapeutic targets to treat GI dysfunction.