Analysis of the regulatory mechanism of IL-17/IL-22 production during bacterial infection

为了阐明细菌感染对IL-17和IL-22产生的调控机制，我们分析了细菌感染过程中Th17细胞和产生IL-17/IL-22的先天淋巴样细胞的时空行为，利用报告小鼠对Th17相关细胞因子进行了可视化。此外，我们还对产生IL-17的细胞和产生IL-22的细胞进行了转录组分析，并探索了可能调节IL-22在Th17细胞或产生IL-17/IL-22的固有淋巴样细胞中的表达的因素。

To clarify the regulatory mechanism of IL-17 and IL-22 production in response to bacterial infection, we analyzed the spatio-temporal behavior of Th17 cells and IL-17/IL-22-producing innate lymphoid cells during bacterial infection, using the reporter mice for visualization of Th17-related cytokine. Furthermore, we performed transcriptome analyses of IL-17-producing cells and IL-22-producing cells, and explored the factors which may regulate the expression of IL-22 in Th17 cells or IL-17/IL-22-producing innate lymphoid cells.