Blood DNA test for breast cancer susceptibility

血液 DNA 检测乳腺癌易感性

• 批准号: 24659278
• 负责人: SUEHIRO Yutaka
• 金额: $ 2.5万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659278/
• 关键词: 膵がん; コピー数多型; 膵癌

Copy number polymorphisms (CNP) is one of genetic variations and involve gains or losses of several to hundreds of kilobases of genomic DNA among phenotypically normal individuals. Recent studies have described associations of CNPs with various common disorders as well as mental illness. Although CNPs are expected to affect pancreatic cancer, little is known about this association. These gap, in our knowledge, prompted us to study this relation. Array comparative genomic hybridization was performed to search for candidate CNPs related to pancreatic cancer susceptibility. We found 10 CNP markers associates with pancreatic cancer risk. The frequency of the CNPs were 55-70% in patients with pancreatic cancer and 0-7% in controls. These findings may lead a new means of risk assessment for pancreatic cancer.

拷贝数多态性（Copy number polymorphisms，CNP）是一种遗传变异，涉及表型正常个体基因组DNA中几个到几百个碱基的获得或丢失。最近的研究已经描述了CNP与各种常见疾病以及精神疾病的关联。虽然CNPs预计会影响胰腺癌，但对这种关联知之甚少。这些差距，在我们的知识，促使我们研究这种关系。进行阵列比较基因组杂交以搜索与胰腺癌易感性相关的候选CNP。我们发现10个CNP标志物与胰腺癌风险相关。胰腺癌患者CNP的频率为55-70%，对照组为0-7%。这些发现可能为胰腺癌的风险评估提供一种新的方法。