性ステロイド依存性腫瘍におけるestradiol局所調節機構の解析

雌二醇在性激素依赖性肿瘤中的局部调控机制分析

• 批准号: 09770108
• 负责人: 鈴木 貴
• 金额: $ 1.02万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09770108/
• 关键词: 17β-HSD; breast; carcinoma; endometrium; estrogen; human; immunohistochemistry; Breast; Estradiol; Endometrium; Human; Retinaic Acid

平成10年度は、ヒト乳癌(90例)及び子宮内膜癌組織(35例)における17β-hydroxysteroid dehydrogenase(17β-HSD)isozymesの発現を免疫組織化学的に検討した。その主な結果は下記の如くである。1。 浸潤性乳管癌では、59%の症例で腫瘍細胞に17β-HSD type 1の発現が見られたが、17β-HSD type 2の発現は認められなかった。2。 17β-HSD type 1の発現が高い群ほど、腫瘍の形態学的分化度がよく、estrogen receptorやprogesterone receptorが多く発現し、またKi-67増殖関連抗原の発現が低い傾向が統計学的に示された。3。 子宮類内膜腺癌では37%の症例において、腫瘍細胞に17β-HSD type 2の発現が見られたが、17β-HSD type 1の発現は見られなかった。4。 腫瘍の形態学的分化度の良い症例ほど17β-HSD type 2の発現が高頻度で認められた。ヒト癌組織における17β-HSD isozymesの発現パターンは、平成9年度のin vitroの実験データと類似し、乳癌と子宮内膜癌では大きく異なっていた。すなはち癌組織におけるestradiolは、乳癌では合成によって制御されるものの、子宮内膜癌では逆に分解によって制御されていると推察された。以上の所見は、乳癌や子宮内膜癌におけるestradiolの局所的役割や腫瘍の増殖形態について考えるうえで大変重要な所見と思われた。

Immunohistochemical staining of 17 β-hydroxysteroid dehydrogenase (17 β-HSD) isozymes was detected in breast cancer (n = 90) and endometrial carcinoma (n = 35) in Pingcheng. The results of the main results are as bad as those of you. one. In 59% of patients with infiltrating breast cancer, 17 β-HSD type 1 and 17 β-HSD type 2 were found. two. 17 β-HSD type 1 showed that the population was high, the differentiation degree of morphology was high, the progesterone receptor of estrogen receptor was much higher, and the antigen of Ki-67 colonization was lower than that of statistical analysis. three. 37% of the cases of endometrial adenocarcinoma were diagnosed as endometrium, 17 β-HSD type 2 and 17 β-HSD type 1 were found to have abnormal symptoms. four. The degree of differentiation in histology, the degree of differentiation, the case of 17 β-HSD type 2, and the high degree of differentiation. The tissue of breast cancer, 17 β-HSD isozymes, and Pingcheng, in vitro, endometrial cancer, breast cancer, breast cancer, endometrial cancer, breast cancer, endometrial cancer, breast cancer, The estradiol of cancer tissue, the synthesis of breast cancer, the reverse decomposition of endometrial cancer and the control of endometrial cancer were studied. Breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, endometrial cancer, breast cancer, endometrial cancer, breast cancer, endometrial cancer

项目成果

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Takaya R 等人：“正常循环人类卵巢中的巨噬细胞；免疫组织化学定位和表征。人类生殖”12・7 1508-1512（1997）。

Suzuki T et al.: "Cyclic changes of vasculature and vascular phenotypes in normal human ovaries." Human Reproduction.13(4). 953-959 (1998)

Suzuki T 等人：“正常人类卵巢中脉管系统和血管表型的周期性变化。”