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Development of New Packing Materials in Chromatography Based on Molecular Recognition Concept

基于分子识别概念的色谱新型填料的开发

基本信息

批准号：
06640781
负责人：
JINNO Kiyokatsu
金额：
$ 1.41万
依托单位：
Toyohashi University of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

In this project, three basic approaches are introduced to propose, design, synthesize and evaluate a novel stationary phase which can offer excellent resolution and selectivity for the separations of polycyclic aromatic hydrocarbons (PAHs) and fullerenes. The steps are based on the molecular recognition mechanism. For PAHs the solutes are two dimensional molecules or steric bulky molecules. Firstly we have evaluated easily available ODS stationary phases for the separation of PAHs and fullerenes and the results provided us with the basic understanding and knowledge for designing novel stationary phases for enhancing selectivity and performance. Secondly stationary phases different from ODS phases were evaluated. In this evaluation various types of phases were synthesized and LC performance has been examined. Many new information about the retention mechanism have been obtained. With this experimentally obtained information novel stationary phases can be designed using computer energy calculations and graphical presentation. And then new phases designed were synthesized by organic reactions in order to understand the experimental results obtained by ODS and other stationary phases. After th confirmation of those results in which selectivity enhancements for PAHs and fullerenes separations are seen, one could PAHs fullerenes. Those new phases were multilegged phenyl group bonded phases and C60 bonded phases which are both new phases in this field. The project has entered into the evaluation of those newly designed and synthesized phases for PAHs and fullerenes separations. The results have clearly indicated the basic molecular recognition mechanism is working very well for the selectivity enhancements of those solutes separations. This approach can show the future trends in designing the tailored stationary phases for the particular separation problems and the value of thisproject is very important in the future separation sciences.

本项目主要介绍了三种基本方法，即提出、设计、合成和评价一种新型的固定相，该固定相可以为多环芳烃和富勒烯的分离提供优异的分辨率和选择性。这些步骤是基于分子识别机制。对于多环芳烃的溶质是二维分子或空间大分子。首先，我们已经评估了易于获得的ODS固定相的多环芳烃和富勒烯的分离和结果为我们提供了基本的理解和知识，设计新的固定相，以提高选择性和性能。其次，对不同于ODS固定相的固定相进行了评价。在该评价中，合成了各种类型的相，并检查了LC性能。获得了许多关于固位机理的新信息。利用这些实验获得的信息，可以使用计算机能量计算和图形表示来设计新的固定相。然后通过有机反应合成新的固定相，以了解ODS和其他固定相的实验结果。在证实了这些结果后，在多环芳烃和富勒烯分离的选择性增强，人们可以多环芳烃富勒烯。这些新相是多支苯基键合相和C60键合相，它们都是该领域的新相。该项目已进入对那些新设计和合成的用于多环芳烃和富勒烯分离的相的评价。结果表明，基本的分子识别机理对提高这些溶质的分离选择性是有效的。这一方法可以为特定的分离问题设计定制的固定相提供一个新的方向，在未来的分离科学中具有重要的应用价值。