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Pathogenicity of anti triose-phosphate isomerase antibody in patients with CNS lupus.

Pathogenicity of anti triose-phosphate isomerase antibody in patients with CNS lupus.
抗丙糖磷酸异构酶抗体在中枢神经系统狼疮患者中的致病性。
批准号:
17591052
负责人:
WATANABE Hiroshi
金额:
$0.7万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006

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中文摘要
翻译
在我们之前的研究中,我们证实了NP狼疮患者血清(14例患者中的7例)和脑脊液(2例患者中的1例)中存在抗三磷酸异构酶(抗tpi)的IgG抗体。此外,抗tpi抗体指数在NP- sle患者中具有高特异性(94.5%),我们得出结论,抗tpi抗体指数是临床上有用的NP-狼疮标志物(Watanabe et al., 2004)。然而,抗tpi在NP狼疮发病机制中的作用尚不清楚。为了确定抗TPI在NP狼疮发病中的作用,我们1)用抗TPI的Western blotting方法分析NP狼疮患者CSF, 2)从NP狼疮患者CSF中分离IC,观察IC中是否含有TPI, 3)测定NP狼疮患者CSF中抗TPI阳性和阴性的C3d指数,研究补体活化是否与NP狼疮CSF中抗TPI的存在有关。应用免疫印迹法检测12例神经精神性狼疮患者中5例(41.6%)脑脊液中抗三磷酸异构酶抗体(anti-TPI)。抗tpi阳性患者脑脊液C3d指数(n=5,中位数0.446)显著高于抗tpi阴性患者脑脊液C3d指数(n=7,中位数0.098)(p=0.019)。2例抗TPI阳性患者中2例从CSF分离的免疫复合物(IC)中检测到TPI, 5例抗TPI阴性患者中5例从IC中未检测到TPI。我们的研究结果表明,抗tpi在CSF中形成IC,并通过激活补体系统参与神经精神性狼疮的发病机制。
英文摘要
In our previous study, we demonstrated the presence of IgG antibodies to triosephosphate isomerase (anti-TPI) in sera (7 of 14 patients) and in CSF (1 of 2 patients) in patients with NP lupus. Furthermore, anti-TPI antibody index has high specificity (94.5%) in patients with NP-SLE, and we concluded that anti-TPI antibody index is a clinically useful marker for NP lupus (Watanabe et al., 2004). However, the role of anti-TPI on NP lupus pathogenesis is not clear. To determine the role of anti-TPI on NP lupus pathogenesis we 1) analyzed CSF of NP lupus patients by Western blotting with anti-TPI, 2) isolated IC from CSF of NP lupus patients and investigated whether the IC contain TPI, and 3) determined C3d index in anti-TPI-positive and negative CSF of NP lupus patients and investigated whether complement activation is associated with the existence of anti-TPI in CSF of NP lupus.We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting. C3d index was significantly higher in anti-TPI-positive patient (n=5, median 0.446) than in anti-TPI-negative patient (n=7, median 0.098) (p=0.019) CSF samples. TPI was detected from immune complexes (IC) isolated from CSF in 2 of 2 anti-TPI-positive patients tested and was not detected from IC in 5 of 5 anti-TPI-negative patients tested. Our results suggest that anti-TPI form IC in CSF and contribute to the pathogenesis of neuropsychiatric lupus by activating the complement system.
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DOI: 10.1016/j.jneuroim.2006.09.003
发表时间: 2006-12
期刊: Journal of Neuroimmunology
影响因子: 3.3
作者: [T. Sasajima;H. Watanabe;S. Sato;Yukio Sato;H. Ohira]
通讯作者: T. Sasajima;H. Watanabe;S. Sato;Yukio Sato;H. Ohira
「研究成果報告書概要(欧文)」より
摘自《研究结果报告摘要(欧洲)》
DOI: --
发表时间: 2006
期刊: Seibutsu Butsuri 46(1)
影响因子: --
作者: [Yasushi Shigeri, Keiko Shimamoto]
通讯作者: Keiko Shimamoto
Followership as a Reflection of Leadership - Middle Manager's Experience and Succession at Work -
  • 批准号:
    18K12856
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 资助金额:
    $1.33万
  • 财政年份:
    2018
  • 负责人:
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"1968" from the Viewpoint of Visual/Auditory Culture: Reconsidering post-war History in Japan
  • 批准号:
    25284036
  • 项目类别:
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  • 资助金额:
    $10.48万
  • 财政年份:
    2013
  • 负责人:
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Identification of novel genetic background and genotype phenotype correlation and development of personalized medicine in arrhythmia syndromes.
  • 批准号:
    24591038
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.33万
  • 财政年份:
    2012
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Feedback between Chain Dynamics and Phase Separation in Polymer Blends
  • 批准号:
    24245045
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $29.45万
  • 财政年份:
    2012
  • 负责人:
    WATANABE Hiroshi
  • 依托单位:
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海外基金
自身免疫性T细胞的抗原决定簇在抗肾小球基底膜病发病中的启动机制
  • 批准号:
    81170645
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2011
  • 负责人:
    崔昭
  • 依托单位:
受体编辑在天然自身反应性B细胞发育耐受中的作用和机制研究
抗肾小球基底膜抗体的免疫学特性在疾病发生和发展中的作用
  • 批准号:
    30700752
  • 项目类别:
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  • 资助金额:
    17.0万元
  • 批准年份:
    2007
  • 负责人:
    崔昭
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