Search for Novel Functionalities of Amino Acids as Bio-regulatory Factors and Verification of Their Usefulness

寻找氨基酸作为生物调节因子的新功能并验证其有用性

• 批准号: 20248014
• 负责人: KADOWAKI Motoni
• 金额: $ 30.45万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20248014/
• 关键词: アミノ酸; マイクロアレイ; 発現制御; 栄養学; シグナル伝達; マクロアレイ

Collaborative works on the signal transduction and cell response to amino acids were undertaken mainly by using DNA microarray analysis. Thus, functionalities of amino acids, not as nutrients, but as signaling molecules, were analyzed regarding the regulation of protein synthesis and degradation, i. e., gene expression and autophagy, the regulations of carbohydrate metabolism and lipid metabolism, and a signaling mechanism of serine availability in the neuronal tissues. Complex information network structures of a variety of amino acids were partially clarified.

在信号转导和细胞对氨基酸的反应方面的协作工作主要是通过DNA微阵列分析进行的。因此，从蛋白质合成和降解的调节，即基因表达和自噬，碳水化合物代谢和脂肪代谢的调节，以及神经组织丝氨酸可利用性的信号机制等方面，分析了氨基酸的功能，而不是作为营养物质，而是作为信号分子。部分阐明了多种氨基酸的复杂信息网络结构。

项目成果

Isoleucine administration downregulates the genes for gluconeogenic rate-limiting enzymes

异亮氨酸给药下调糖异生限速酶基因

• 发表时间: 2010
• 作者: S.-W. Kim;M. Miyahara;S. Fushinobu;T.Wakagi;and H. Shoun;Nodoka Oikawa
• 通讯作者: Nodoka Oikawa

PEPCK2遺伝子のアミノ酸応答配列近傍領域の機能解析

PEPCK2基因氨基酸响应序列附近区域的功能分析

• 发表时间: 2008
• 作者: 石井駿介;加藤久典
• 通讯作者: 加藤久典

Vitamin E as a novel enhancer of macroautophagy in rat hepatocytes and H4-II-E cells

• DOI: 10.1016/j.bbrc.2010.03.103
• 发表时间: 2010-04-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Karim, Md. Razaul;Fujimura, Shinobu;Kadowaki, Motoni
• 通讯作者: Kadowaki, Motoni

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Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver

• DOI: 10.1677/jme-10-0102
• 发表时间: 2010-11-01
• 期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY
• 影响因子: 3.5
• 作者: Toyoshima, Yuka;Tokita, Reiko;Takahashi, Shin-Ichiro
• 通讯作者: Takahashi, Shin-Ichiro