Search for Novel Functionalities of Amino Acids as Bio-regulatory Factors and Verification of Their Usefulness

主要通过使用DNA微阵列分析进行信号转导和细胞对氨基酸的反应的合作工作。因此，氨基酸的功能，而不是作为营养素，但作为信号分子，分析了蛋白质合成和降解的调节，即。例如，基因表达和自噬，糖代谢和脂质代谢的调节，以及神经元组织中丝氨酸可用性的信号传导机制。部分阐明了多种氨基酸的复杂信息网络结构。

Collaborative works on the signal transduction and cell response to amino acids were undertaken mainly by using DNA microarray analysis. Thus, functionalities of amino acids, not as nutrients, but as signaling molecules, were analyzed regarding the regulation of protein synthesis and degradation, i. e., gene expression and autophagy, the regulations of carbohydrate metabolism and lipid metabolism, and a signaling mechanism of serine availability in the neuronal tissues. Complex information network structures of a variety of amino acids were partially clarified.