Search for Novel Functionalities of Amino Acids as Bio-regulatory Factors and Verification of Their Usefulness

在信号转导和细胞对氨基酸的反应方面的协作工作主要是通过DNA微阵列分析进行的。因此，从蛋白质合成和降解的调节，即基因表达和自噬，碳水化合物代谢和脂肪代谢的调节，以及神经组织丝氨酸可利用性的信号机制等方面，分析了氨基酸的功能，而不是作为营养物质，而是作为信号分子。部分阐明了多种氨基酸的复杂信息网络结构。

Collaborative works on the signal transduction and cell response to amino acids were undertaken mainly by using DNA microarray analysis. Thus, functionalities of amino acids, not as nutrients, but as signaling molecules, were analyzed regarding the regulation of protein synthesis and degradation, i. e., gene expression and autophagy, the regulations of carbohydrate metabolism and lipid metabolism, and a signaling mechanism of serine availability in the neuronal tissues. Complex information network structures of a variety of amino acids were partially clarified.