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Development and application of the shark single chain monoclonal antibody for the treatment of fish and shellfish diseases

Development and application of the shark single chain monoclonal antibody for the treatment of fish and shellfish diseases
鲨鱼单链单克隆抗体治疗鱼贝类疾病的开发及应用
批准号:
21248025
负责人:
AOKI Takashi
金额:
$21.55万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Cartilaginous fish possess a unique immunoglobulin new antigen receptor(IgNAR) which is composed of only two heavy chains. Because of its simple and unique structure, the variable region of the shark IgNAR is suitable for the production of an artificial monoclonal antibody against fish and shellfish pathogens. Here, we cloned cDNA encoding IgNAR from the banded houndshark Triakis scyllium. The phage display library, possessing a variable region of the IgNAR, was constructed and clones specifically binding to a certain antigen were isolated
期刊论文(11)
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会议论文
DOI: 10.1016/j.fsi.2010.07.034
发表时间: 2010-11-01
期刊: FISH & SHELLFISH IMMUNOLOGY
影响因子: 4.7
作者: [Honda, Yuka, Kondo, Hidehiro, Aoki, Takashi]
通讯作者: Aoki, Takashi
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [大谷真紀, 引間順一, 近藤秀裕, 廣野育生, Jung TS, 青木宙]
通讯作者: 青木宙
Isolation of antigen specific V-region molecule from artificially randomized IgNAR phage display library
从人工随机 IgNAR 噬菌体展示文库中分离抗原特异性 V 区分子
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ohtani M, Hikima J, Kondo H, Hirono I, Jung TS, Aoki T]
通讯作者: Aoki T
DOI: 10.1016/j.vetimm.2009.09.005
发表时间: 2010-04-15
期刊: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子: 1.8
作者: [Kondo, Hidehiro, Darawiroj, Damri, Aoki, Takashi]
通讯作者: Aoki, Takashi
6
    Creation of coacervate interfaces for controlling fouling behavior
    • 批准号:
      16K14047
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2016
    • 负责人:
      AOKI Takashi
    • 依托单位:
    The metaphysics in "Tianfang Xingli" by Liu Zhi as Mulim Intellectual in Qing Dynasty
    • 批准号:
      24520045
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2012
    • 负责人:
      AOKI Takashi
    • 依托单位:
    Bio-synthesis of poly(lactic acid) by wild type PHA-producing bacteria
    • 批准号:
      23655145
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      AOKI Takashi
    • 依托单位:
    Development of growth inhibition of fish pathogenic virus by RNA aptamers
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