Development and application of the shark single chain monoclonal antibody for the treatment of fish and shellfish diseases
Development and application of the shark single chain monoclonal antibody for the treatment of fish and shellfish diseases
批准号:
21248025
负责人:
AOKI Takashi
金额:
$21.55万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Cartilaginous fish possess a unique immunoglobulin new antigen receptor(IgNAR) which is composed of only two heavy chains. Because of its simple and unique structure, the variable region of the shark IgNAR is suitable for the production of an artificial monoclonal antibody against fish and shellfish pathogens. Here, we cloned cDNA encoding IgNAR from the banded houndshark Triakis scyllium. The phage display library, possessing a variable region of the IgNAR, was constructed and clones specifically binding to a certain antigen were isolated
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DOI:
10.1016/j.fsi.2010.07.034
发表时间:
2010-11-01
期刊:
FISH & SHELLFISH IMMUNOLOGY
影响因子:
4.7
作者:
[Honda, Yuka, Kondo, Hidehiro, Aoki, Takashi]
通讯作者:
Aoki, Takashi
ランダム化したドチザメIgNARファージディスプレイライブラリーからの抗原特異的なクローンの選択
从随机褐鲨 IgNAR 噬菌体展示文库中选择抗原特异性克隆
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大谷真紀, 引間順一, 近藤秀裕, 廣野育生, Jung TS, 青木宙]
通讯作者:
青木宙
Isolation of antigen specific V-region molecule from artificially randomized IgNAR phage display library
从人工随机 IgNAR 噬菌体展示文库中分离抗原特异性 V 区分子
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ohtani M, Hikima J, Kondo H, Hirono I, Jung TS, Aoki T]
通讯作者:
Aoki T
DOI:
10.1016/j.vetimm.2009.09.005
发表时间:
2010-04-15
期刊:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子:
1.8
作者:
[Kondo, Hidehiro, Darawiroj, Damri, Aoki, Takashi]
通讯作者:
Aoki, Takashi
ドチザメIgNAR人工組換え体の作製に関する研究
人工重组褐鲨IgNAR的生产研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[隅田慧光, 廣野育生, 青木宙, 近藤秀裕]
通讯作者:
近藤秀裕
共 6 条
Creation of coacervate interfaces for controlling fouling behavior
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批准号:16K14047
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2016
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负责人:AOKI Takashi
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依托单位:
The metaphysics in "Tianfang Xingli" by Liu Zhi as Mulim Intellectual in Qing Dynasty
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批准号:24520045
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资助金额:$3.16万
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Bio-synthesis of poly(lactic acid) by wild type PHA-producing bacteria
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批准号:23655145
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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Development of growth inhibition of fish pathogenic virus by RNA aptamers
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批准号:22658059
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.34万
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财政年份:2010
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负责人:AOKI Takashi
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依托单位:
Asymptotic analysis of instanton-type solutions
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批准号:22540210
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2010
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Trial of the First Year Education for Acquiring Exercise Habits- A Case of Using Portfolio -
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批准号:22500592
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.25万
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财政年份:2010
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负责人:AOKI Takashi
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依托单位:
Archeological study on genealogy of the engineering works technology in ancient Japan and Korea
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批准号:21720294
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.91万
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财政年份:2009
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负责人:AOKI Takashi
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依托单位:
Exact WKB analysis of systems of differential equations
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批准号:18540197
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2006
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负责人:AOKI Takashi
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依托单位:
Chinese philosophy and Sufi theory of "Tianfang Xingli(天方性理)" written by Liu ZHI(劉智) Who is a Chinese Moslem scholar in Qing Dynasty
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批准号:16520037
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.57万
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财政年份:2004
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负责人:AOKI Takashi
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依托单位:
Development of DNA microarray for characterization of gene network systems of fish and shellfish
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批准号:15108003
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$67.23万
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财政年份:2003
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负责人:AOKI Takashi
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依托单位:
Exact WKB analysis of microdifferential equations of infinite order
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批准号:15540190
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:AOKI Takashi
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依托单位:
MOLECULAR STRATEGIES OF TRYPANOSOMA CRUZI IN REMODELING AND CONTROLLING THE INFECTED HOST CELLS
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批准号:15390138
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2003
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负责人:AOKI Takashi
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依托单位:
Development of DNA vaccines for fish
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批准号:12556031
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.26万
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财政年份:2000
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负责人:AOKI Takashi
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依托单位:
Molecular characterization of all the six enzymes and their corresponding genes involved in de novo pyrimidine biosynthesis in trypanosomatids
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批准号:12470061
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:2000
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负责人:AOKI Takashi
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依托单位:
WKB analysis for high-order ordinary differencial equations with a large parameter
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批准号:12640195
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:2000
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负责人:AOKI Takashi
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依托单位:
Molecular mechanisms regulating globin gene expression in fish
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批准号:11694198
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.9万
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财政年份:1999
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负责人:AOKI Takashi
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依托单位:
Virulence, infection, and pathogenicity related genes of fish pathogens
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批准号:10460085
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.74万
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财政年份:1998
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负责人:AOKI Takashi
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依托单位:
Mechanism of Rotation of a Thick X-Y-Z-cut Crystal
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批准号:09650069
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.58万
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财政年份:1997
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负责人:AOKI Takashi
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依托单位:
Algebraic Analysis of Exponential Asymptotics
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批准号:09640234
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.58万
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财政年份:1997
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负责人:AOKI Takashi
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依托单位:
Genetic variation of disease resistance in fish
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批准号:08045051
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$4.42万
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财政年份:1996
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负责人:AOKI Takashi
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依托单位:
海外基金