Causes of the Biliary Tract Cancer from the Point of View of Environmental Epidemiology
从环境流行病学角度探讨胆道癌的成因
基本信息
- 批准号:01570286
- 负责人:
- 金额:$ 1.09万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1989
- 资助国家:日本
- 起止时间:1989 至 1990
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1) Rec assay of human bileEpidemiological studies revealed that the death rate for the biliary tract cancer in Niigata Prefecture has been the highest in japan since 1958. In order to examine whether or not the human bile in Niigata is mutagenic, we tested the bile collected in Niigata by means of rec assay and compared with the rate of mutagenic activity of the bile in Kochi Prefecture, where the death rate has been relatively low in Japan. Spore rec assay of human bile was conducted by the Bacillus subtilis test system to examine possible mutagenicity and co-mutagenicity. Of 65 samples in Niigata Prefecture examined, 3(4.6%) Showed mutagenic activity. In 26 samples in Kochi Prefecture, none was mutagenic. There was no statistical significance in frequencies of mutagenicity between Niigata and Kochi Prefectures.(2) Selenium contents in human gallbladder bileThe selenium contents in human gallbladder bile were analyzed. Thirty- Seven subjects were studied ; 22 Patients with cholelithiasis in Niigata and 15 patients (13 with cholelithiasis and 2 with gallbladder polypus) in Kochi Prefecture. Five ml of bile was withdrawn withdrawn with a syringe from the gallbladder during the operation and stored at -20^゚C until analysis. For the analysis by gas chromatograph with an electron-capture detector, 0.2 ml of sample was used. The mean selenium contents in bile were 269 <plus-minus>39.0 (mean<plus-minus>S.D.) ng/ml for the subjects in Niigata and 285 <plus-minus>84.4ml in Kochi ; without significant difference.
(1)人体胆汁的REC分析流行病学研究显示,自1958年以来,新泻县的胆道癌死亡率一直是日本最高的。为了检验新泻地区的人胆汁是否具有致突变性,我们对新泻地区采集的胆汁进行了REC试验,并与日本死亡率较低的高知县的胆汁致突变率进行了比较。用枯草芽孢杆菌检测系统对人胆汁进行孢子重组试验,以检测可能的致突变性和共致突变性。在新泻县检测的65份样品中,有3份(4.6%)显示出致突变活性。在高知县的26个样本中,没有一个是诱变的。新泻县和高知县的诱变率差异无统计学意义。(2)人体胆汁中的硒含量。研究对象为37名受试者:新泻县22例胆石症患者和高知县15例患者(胆石症13例,胆囊息肉2例)。术中用注射器从胆囊部取出胆汁5毫升,保存于-20℃゚℃进行分析。使用带有电子捕获检测器的气相色谱仪进行分析,使用0.2毫升样品。胆汁中硒的平均含量为269+gt;39.0(平均值+lt;++gt;S.D.)新泻为84.4ml,高知为84.4ml,无显著差异。
项目成果
期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
山本 正治 他: "胆道癌 1)記述疫学" 胆肝膵. 22. (1991)
Masaharu Yamamoto 等人:“胆道癌 1) 描述性流行病学”Bilihepatopancreas 22。(1991)
- DOI:
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- 影响因子:0
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- 通讯作者:
陳 偉師 他: "Selenium Contents in Human Gallbladder Bile" Tohoku J.Exp.Med.161. 257-259 (1990)
Weishi Chen 等人:“人胆囊胆汁中的硒含量”Tohoku J.Exp.Med.161 (1990)。
- DOI:
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- 影响因子:0
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遠藤和男,山本正治: "日本人の胆石症・胆道がんの変遷" 総合臨床. 38. 2559-2565 (1989)
Kazuo Endo、Masaharu Yamamoto:“日本人胆石症和胆道癌的变化”《一般临床实践》38. 2559-2565 (1989)。
- DOI:
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- 影响因子:0
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SHIBUYA, NORIO et al.: "Co-mutagenic activity of phenoxyherbicides MCPA-and MCPB-ethylesters in the Ames assay" Tohoku J. Exp. Med.160. 167-168 (1990)
SHIBUYA、NORIO 等人:“Ames 测定中苯氧除草剂 MCPA 和 MCPB 乙酯的共诱变活性”Tohoku J. Exp。
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- 影响因子:0
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- 通讯作者:
渋谷 範夫 他: "CoーMutagenic Activity of Phenoxyherbicides MCPAーand MCPBーEthylesters in the Ames Assay" Tohoku J.Exp.Med.160. 167-168 (1990)
Norio Shibuya 等人:“Ames 测定中苯氧除草剂 MCPA-和 MCPB-乙基酯的共同诱变活性”Tohoku J.Exp.Med.167-168 (1990)。
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- 影响因子:0
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YAMAMOTO Masaharu其他文献
YAMAMOTO Masaharu的其他文献
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{{ truncateString('YAMAMOTO Masaharu', 18)}}的其他基金
Environmental and genetic risk factors for gallbladder cancer in Bolivian people
玻利维亚人胆囊癌的环境和遗传危险因素
- 批准号:
21590650 - 财政年份:2009
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
International and Epidemiological Studies on the Causes of Gallbladder Cancer in Hungary
关于匈牙利胆囊癌病因的国际和流行病学研究
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15406025 - 财政年份:2003
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Concentrations of Free Fatty Acids in Human Bile Juice Collected from Patients with Gallstones in Chile
从智利胆结石患者收集的人胆汁中游离脂肪酸的浓度
- 批准号:
13670332 - 财政年份:2001
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analytical Studies on Extraction and Identification of Carcinogenic Substances from Chili Pepper in Chile
智利辣椒中致癌物质的提取与鉴定分析研究
- 批准号:
11670339 - 财政年份:1999
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Epidemiological Studies on Free Fatty Acid Concentrations in Human Gallbladder Bile from the Point of View of Antimutagencity
从抗诱变角度对人胆囊胆汁中游离脂肪酸浓度的流行病学研究
- 批准号:
08670387 - 财政年份:1996
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on the Etiology of Gallbladder Cancer in Chile
智利胆囊癌的病因学研究
- 批准号:
07042003 - 财政年份:1995
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for international Scientific Research
Epidemiological Studies on Mutagenicity of Human Bile
人胆汁致突变性的流行病学研究
- 批准号:
06670376 - 财政年份:1994
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Epidemiological Studies on Biliary Tract Cancer in Niigata, Japan
日本新泻县胆道癌的流行病学研究
- 批准号:
04670307 - 财政年份:1992
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
フェノキシ系除草剤の発癌性に関する遺伝毒性学的研究
苯氧基除草剂致癌性的基因毒理学研究
- 批准号:
62570227 - 财政年份:1987
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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