Environmental and genetic risk factors for gallbladder cancer in Bolivian people

玻利维亚人胆囊癌的环境和遗传危险因素

• 批准号: 21590650
• 负责人: YAMAMOTO Masaharu
• 金额: $ 3万
• 依托单位: Niigata University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590650/
• 关键词: 胆嚢がん; 症例-対照研究; 環境要因; 遺伝要因; 国際情報交換; ボリビア

We measured the concentrations of aflatoxins in Bolivian red chili pepper, and then determined whether aflatoxin-contaminated red chili pepper consumption is the cause of the development of gallbladder cancer. Aflatoxin B1 was detected at concentration of 11.3 ppb from 1 sample. However the concentrations of several red chili peppers were less than the detection limit of our analysis method. Since our findings suggest that the low-level but protracted exposure to aflatoxins may be associated with the development of gallbladder cancer, further studies, such as investigation of the background of contaminants, are needed.

我们测量了玻利维亚红辣椒中黄曲霉毒素的浓度，然后确定黄曲霉毒素污染的红辣椒消费是否是胆囊癌发展的原因。从1份样品中检出黄曲霉毒素B1，浓度为11.3 ppb。然而，几种红辣椒的浓度低于我们的分析方法的检测限。由于我们的研究结果表明，低水平，但长期暴露于黄曲霉毒素可能与胆囊癌的发展，进一步的研究，如调查的污染物的背景，是必要的。

项目成果

Mutagenicity and mutagens of the red chili pepper as gallbladder cancer risk factor in Chilean women

红辣椒的致突变性和致突变剂作为智利女性胆囊癌的危险因素

• 发表时间: 2011
• 期刊: Asian Pac J Cancer Prev
• 作者: Tsuchiya Y;Terao M;Okano K;Nakamura K;Oyama M;Ikegami K;Yamamoto M
• 通讯作者: Yamamoto M

Polimorfismo genetico relacionado al metabolismo de la aflatoxina y el riesgo de cancer vesicular en mujeres chilenas

智利女性黄曲霉毒素与癌症水泡的遗传关系多态性

• 期刊: Revista Gastroenterologia Latinoamericana
• 作者: Tsuchiya Y;Baez S;Calvo A;Pruyas M;Nakamura K;Kiyohara C;Endoh K;Asai T;Yamamoto M
• 通讯作者: Yamamoto M

Aflatoxin contamination of red chili pepper as a risk factor for gallbladder cancer in Chilean women

红辣椒中的黄曲霉毒素污染是智利女性胆囊癌的危险因素

• 发表时间: 2010
• 作者: Tsuchiya Y;Serra I;Endoh K;Yamamoto M
• 通讯作者: Yamamoto M