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Studies on development of HFRS vaccine and therapeutics

HFRS疫苗和治疗方法的开发研究

基本信息

批准号：
05044144
负责人：
ARIKAWA Jiro
金额：
$ 7.68万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05044144/
关键词：
Hemorrhagic fever with renal syndrome HFRS Hantavirus Vaccine Hantavirus

项目摘要

1.In 1993 and 1995, head investigator (Dr. Arikawa), and Japanese investigators (Drs. Hashimoto, Morimatsu, Kariwa) visited Swedish Institute for Infectious Disease control, and Helsinki University Institute for Virology and made information exchange and discussions along with this research project.2.In 1993, Chinese investigators (Dr. Song and Hun), in 1995, Swedish investigators (Drs. Niklasson and Lundkvist) visited institutions of Japanese investigator such as Hokkaido University, National Institute Health of Japan and Osaka University to do information exchange and discussions along with this research project.3.In 1994, Japanese investigator, Dr. Morimatsu, stayd at Swedish Institute for Infectious Disease control for 2 months to accomplish technical exchange concerning to antibody measurements by ELISA with reduced level of nonspecific background reaction and material exchange of monoclonal antibodies.4.In 1994, Chinese investigator, Dr. Zhou, stayd at Hokkaido University for 6 m … More onths and neutralizing antibody response of vaccinee sera from China was examined. To measure the antibody, ELISA system which established by Swedish investigator and recombinant antigen which produced by Japanese investigator, were effectively applied. The obtained result was important for assess efficacy of Chinese vaccine.5.In 1994, head investigator (Dr. Arikawa) visited the institute of Chinese investigator (Chinese Academy of Preventive Medicine) for discussing this research project and carried out preliminary field survey for collecting wild rodents.6.In 1995, Japanese investigators, Drs. Sugiyama and Ami of National Institute of Health Japan, visited the Chinese Academy of Preventive Medicine and carried out field survey at suburbs of Beijing and Xian to collect field rodents. They examined the antigen distribution in the rodents by histochemical observations. Through the investigation, they established the system for collecting wild animals organs under the collaboration of Chinese investigators and examine viruses in the organs. This survey system will contribute for future collaboration study. Less

1.1993年和1995年，首席调查员（Arikawa博士）和日本研究人员桥本、森松、嘉里和博士随本研究项目访问了瑞典传染病控制研究所和赫尔辛基大学病毒学研究所，并进行了沿着的信息交流和讨论。（宋博士和匈奴），1995年，瑞典研究人员（Drs. Niklasson and Lundkvist）访问了日本研究者的机构，如北海道大学、日本国立卫生研究所和大坂大学，沿着本研究项目进行信息交流和讨论。Morimatsu博士在瑞典传染病控制研究所停留了2个月，完成了关于ELISA检测抗体的技术交流，降低了非特异性背景反应的水平，并进行了单克隆抗体的材料交换。 ...更多信息对来自中国的疫苗接种者血清的月龄和中和抗体应答进行了检测。在抗体检测方面，采用了瑞典人建立的ELISA体系和日本人生产的重组抗原。本研究结果对评价国产疫苗的免疫效果具有重要意义（有川博士）访问中国研究者协会1995年，日本国立卫生研究所的杉山博士和阿美博士，访问了中国预防医学科学院，并在北京和西安郊区进行了野外调查，收集了野外啮齿动物。他们通过组织化学观察检查了啮齿动物中的抗原分布。通过调查，他们在中国调查人员的合作下建立了收集野生动物器官的系统，并检查了器官中的病毒。该调查系统将有助于未来的合作研究。少