Kontrollpunkte, welche die Stammzellfunktion und den Organerhalt in Antwort auf Telomerdysfunktion hemmen

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Telomere shortening limits proliferation of human cells to a finite number of cell division by inducing cell cycle arrest, senescence, or apoptosis in response to telomere dysfunction. These checkpoints can limit stem cell function, regeneration and organ homeostasis during ageing and chromic disease. In the proposed project we will analyse the functional influence of specific genes of the ATM/p53-cell cycle checkpoint (Exo1, 53bp1, Chk2) in restraining stem cell function, regeneration and organ homeostasis in response to telomere dysfunction and ageing in telomerase knockout mice. In addition, we will conduct an in vivo screen aiming to identify new genes limiting hematopoietic stem cell maintenance and function in response to telomere dysfunction.