Regulation of the function of adhesion molecule SgIGSF/TSLC1 by shedding and splicing
Regulation of the function of adhesion molecule SgIGSF/TSLC1 by shedding and splicing
批准号:
19590391
负责人:
ITO Akihiko
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
SgIGSF(spermatogenic immunoglobulin superfamily)/TSLC1(tumor suppressor in lung cancer-1)は、免疫グロブリン・スーパーファミリーに属する細胞膜1回貫通型の接着分子で、様々な細胞に発現しており、精子形成やシナプス形成など種々の機能を有するが、本分子の機能制御の仕組みについてはよくわかっていない。本研究課題では、SgIGSF/TSLC1の発現制御機構として転写調節(splicingによる分泌型分子の産生)と転写後調節(sheddingによる細胞外ドメイン断片の産生)が存在することを明らかにした。加えて、分泌型分子は細胞外に放出された後、神経突起上に発現する膜貫通型分子とtrans-ホモフィリックに結合することにより、神経突起の伸長方向の制御に関わることがわかった。
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CADM1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions
CADM1是一种新型胰岛细胞粘附分子,介导神经-胰岛细胞相互作用
DOI:
--
发表时间:
2008
期刊:
Gastroenterology 134
影响因子:
--
作者:
[Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A]
通讯作者:
Ito A
CADMl is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions
CADM1是介导神经-胰岛细胞相互作用的新型胰岛细胞粘附分子
DOI:
--
发表时间:
2008
期刊:
Gastroenterology (In press)
影响因子:
--
作者:
[Ito A, Hagiyama M, Oonuma J, Koma Y, Ito A, Ito A, Koma Y]
通讯作者:
Koma Y
CADM1 : a new mast-cell adhesion molecule that mediates interaction with fibroblasts, nerves, and smooth muscles in Mast Cells : Roles, Interactions and Disorders (eds, Jonas F. Jung and Luca T. Scholz)
CADM1:一种新的肥大细胞粘附分子,介导肥大细胞中与成纤维细胞、神经和平滑肌的相互作用:角色、相互作用和障碍(编辑,Jonas F. Jung 和 Luca T. Scholz)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ito A, Hagiyama M]
通讯作者:
Hagiyama M
DOI:
10.1074/jbc.m608562200
发表时间:
2007-06-29
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Yabuta, Norikazu, Okada, Nobuhiro, Nojima, Hiroshi]
通讯作者:
Nojima, Hiroshi
Meijer CJLM and Steenbergen RDM : Association of dense CADM1 promoter methylation and reduced protein expression in high-grade ICN and cervical SCC
Meijer CJLM 和 Steenbergen RDM:高级别 ICN 和宫颈 SCC 中密集 CADM1 启动子甲基化与蛋白表达减少的关联
DOI:
--
发表时间:
2008
期刊:
J Pathol 215
影响因子:
--
作者:
[Overmeer RM, Snijders PJF, Claassen-Kramer D, Berkhof J, Helmerhorst TJM, Heideman DAM, Wilting SM, Ito A, Murakami Y]
通讯作者:
Murakami Y
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