Uncinate fasciculus alternations in drug naive schizophrenia: A diffusion tensor imaging study
Uncinate fasciculus alternations in drug naive schizophrenia: A diffusion tensor imaging study
批准号:
19591368
负责人:
INOUE Makoto
金额:
$0.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
未投薬状態の統合失調症罹患患者21名に対して拡散協調画像を撮像し、あわせて臨床症状、認知機能検査を実施した。 その後得られた拡散強調画像から鈎状束の繊維走行を描出し得られた走行に属するvoxel群のFA値、ADC値を検討に用いた。 その結果左右の鈎状束において疾患罹患者のFA値の低下とADC値の上昇傾向が認められた。また疾患罹患者の臨床症状や認知機能とFA値、ADC値において有意な相関は認められなかった。本結果は従来の報告を支持し統合失調症において白質病変の存在を示唆するものと思われた。
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