Functional role of rostral trigeminal interneurons during mastication

咀嚼过程中头侧三叉神经中间神经元的功能作用

• 批准号: 14571760
• 负责人: INOUE Makoto
• 金额: $ 2.43万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571760/
• 关键词: mastication; coordination jaw and tongue movements; electromyography; premotorneuron; tongue muscle; jaw muscle; 嚥下; 感覚のフィードバック; 動物; 節電図; 単一神経活動; 三叉神経運動核; 三叉神経上域; 三叉神経間域; 三叉神経脊髄路核吻側亜核; 咬筋神経

The aim of this research was (1)to investigate the neurophysiological characteristics of premotor neurons which are involved in the masticatory function and (2)to investigate how the activity of jaw, tongue infrahyoid motoneurons are coordinated during mastication.During fictive mastication in the anesthetized animal, the styloglossus (tongue-retruder, SG) and masseter (jaw-closer) muscle activities were increased very significantly when the wooden stick was applied between the molar teeth. This may be due to the stimulation of the periodontal mechanoreceptors and also the muscle spindles.During natural mastication, activity of masseter, digastric (jaw-opener), mylohyoid (suprahyoid, MH), SG and genioglossus (tongue-protruder, GG) muscles were recorded. Each masticatory cycle had three components including the fast-closing, slow-closing(SC) and opening(Op) phases. The MH muscle exhibited double-peaked bursts during the Op phase. The MH burst in the late part of the Op phase was dominant on the non-chewing side during pellet and bread chewing. The SG muscle also exhibited double-peaked bursts in one masticatory cycle. During pellet and bread chewing, the SG bursts during the SC phase were significantly larger on the chewing side than the non-chewing side. These bursts were also dominant during pellet chewing as compared with banana chewing. The results suggest that the suprahyoid and tongue muscles could play a critical role in completing mastication.Regarding the premotor neurons projecting to the trigeminal, facial and hypoglossus motor nuclei, no interneuron was found to project to more than two nuclei with bifurcation. Although many premotor neurons receive inputs from peripheral nerves, these interneurons do not seem to control the coordination of jaw, tongue and facial movements during mastication, but just relay the inputs from the masticatory central rhythm generator in the brain stem.

这项研究的目的是（1）研究涉及咀嚼功能的前神经元的神经生理特征，以及（2）调查如何在咀嚼过程中调查颌骨，舌舌肠球类动物元的活动。当摩尔牙齿之间施加木棍时，活动的增加非常明显。这可能是由于牙周机械感受器的刺激以及肌肉纺锤体的刺激。在自然咀嚼，咬合者的活性，digastric（jaw-opener），肌羟基（suprahoid，MH），sg和Genioglossus（舌形刺激器，舌形刺激器，gg）肌肉记录下来。每个咀嚼周期都有三个组件，包括快速关闭，缓慢的（SC）和开放阶段（OP）阶段。 MH肌肉在OP阶段表现出双峰爆发。在OP阶段晚期的MH爆发在颗粒和面包咀嚼期间的非咀嚼侧占主导地位。 SG肌肉在一个咀嚼周期中还表现出双峰爆发。在颗粒和面包咀嚼期间，SC阶段的SG爆发在咀嚼侧明显大于非咀嚼侧。与香蕉咀嚼相比，在颗粒咀嚼过程中，这些爆发也占主导地位。结果表明，肌肌和舌头肌肉在完成咀嚼方面可能起关键作用。主看投射到三叉神经，面部和hypoglossus运动核的前神经元，没有发现任何interneuron可以投射到两个以上的核中。尽管许多前神经元从周围神经接收输入，但这些中间神经元似乎无法控制咀嚼过程中下颌，舌头和面部运动的配位，而只是将输入的输入转移到脑干中的乳胶中心节奏产生器。

项目成果

Electromyographic activity of genioglossus muscle during orofacial function in humans

人类口面部功能期间颏舌肌的肌电活动

• 发表时间: 2004
• 期刊: Nihon Gakukohku Kinoh Gakkai Zasshi 11
• 作者: Inoue;M.
• 通讯作者: M.

Y.Kajii: "Sour taste stimulation facilitates reflex swallowing from the pharynx and larynx in the rat"Physiol Behav. 77. 321-325 (2002)

Y.Kajii：“酸味刺激促进大鼠咽部和喉部的反射性吞咽”生理行为。

Activity of peri-oral facial muscles and its coordination with jaw muscles during ingestive behavior in awake rabbits.

清醒兔子摄食行为期间口周面部肌肉的活动及其与下颌肌肉的协调。

• 发表时间: 2004
• 期刊: Brain Res. 1001・1-2
• 作者: Ootaki;S.
• 通讯作者: S.

Extrinsic tongue and suprahyoid muscle activities during mastication in freely feeding rabbits.

自由喂养兔子咀嚼过程中的外在舌头和舌骨上肌活动。

• 发表时间: 2004
• 期刊: Brain Res. 1021・2
• 作者: Inoue;M.
• 通讯作者: M.

S.Abe: "Experimental device for detecting laryngeal movement during swallowing"The Bulletin of Tokyo Dental College. 43. 199-203 (2002)

S.Abe：“检测吞咽时喉部运动的实验装置”东京齿科大学通报。