A study on acceleration of bone resorption by immunized cells
A study on acceleration of bone resorption by immunized cells
批准号:
19592389
负责人:
HARA Yoshitaka
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
細菌と免疫系が歯周炎の発症に重要な関わりをもつことは、既に知られている。しかし実際の関与の様式は明らかでなかった。本研究では免疫系細胞のうちT細胞に焦点を合わせ、細菌由来のリポ多糖(LPS)誘導型骨吸収におけるその関与を検討した。その結果、T細胞は単独(B細胞不在下)でもLPS誘導型骨吸収に促進的に働くこと、さらに感作された個体のT細胞は骨吸収局所において、その促進作用を発揮していることを明らかにした。
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会议论文
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依托单位:
海外基金