DEVELOPMENT OF CANCER CHEMO-IMMUNOTHERAPEUTIC SYSTEM USING REDOX CONTROLLABLE DDS

我们试图通过有效抑制活性氧来开发治疗系统，活性氧在各种疾病中的参与引起了广泛的关注，包括癌症，炎症和生命相关疾病。我们合成了具有不同组织分布特征的过氧化氢酶衍生物，并在有或没有明胶水凝胶的情况下开发了持久的系统。这些系统在小鼠疾病模型中的应用已经证明它们在抑制结肠癌细胞的腹膜扩散和改善胰岛素抵抗方面是有效的。

We tried to develop therapeutic systems by efficiently inhibiting reactive oxygen species, which have attracted much attention on the involvement in a variety of diseases, including cancer, inflammation and life-related diseases. We synthesized catalase derivatives with diverse tissue distribution characteristics and, with or without gelatin hydrogels, developed long-lasting systems. The application of these systems to mouse disease models have proved that they are effective in inhibiting the peritoneal dissemination of colon carcinoma cells and in ameliorating the insulin resistance.