Reincorporation of cathepsin D in neurons of mouse brain.

点击翻译按钮获取中文摘要

Central nervous system specific cathepsin D (CD) deficient mice (CD:NesCre) ied around P40 by seizures and their phenotype was similar to neuronal ceroid lipofuscinosis. We noticed that CD protein was detected in neurons of CD:NesCre mice by immunohistochemistry, although CD mRNA was not expressed in the neurons. These results indicate that CD:NesCre neurons receive CD from other type of cells. We have also developed the chick experimental model to examine the transport system of lysosomal enzymes and established the stable expression system of transgenes into chick genome.