Gene expression profile of tonsils of patients with IgA nephropathy

IgA肾病患者扁桃体基因表达谱

• 批准号: 20590957
• 负责人: IMAI Enyu
• 金额: $ 3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590957/
• 关键词: IgA腎症; マイクロアレイ; APOBEC2; 遺伝子解析; 腎臓内科学; IA腎症; 腎臓; 扁桃腺; 腎臟内科学

We analyzed the gene expression in the tonsils of patients with IgA nephropathy (N=23) using microarray, compared with those with patients suffering from chronic tonsillitis without IgAN (N=22). We confirmed12 up-regulated genes including APOBEC2, CALB2, DUSP27, and CXCL11. APOBEC2 was positively stained in the epithelium and the peripheral region of the germinal center. The APOBEC2 was confirmed to be elevated in the tonsils in another 73 IgAN patients. These results suggest that the APOBEC2 might be associated with development of IgAN.

应用基因芯片技术对23例IgA肾病患者和22例非IgA肾病慢性扁桃体炎患者的扁桃体基因表达进行分析。我们证实了12个上调基因，包括APOBEC2、CALB2、DUSP27和CXCL11。APOBEC2在生发中心的上皮区和周边区呈阳性染色。另有73例IgAN患者扁桃体APOBEC2升高。提示APOBEC2基因可能与IgAN的发生发展有关。

项目成果

Early plasma exchange for progressive liver failure in recipients of adult-to-adult living-related liver transplants

成人至成人活体相关肝移植受者进行性肝衰竭的早期血浆置换

• 发表时间: 2009
• 期刊: Blood Purif 28
• 作者: Yamamoto R;Nagasawa Y;Marubashi S;Furumatsu Y;Iwatani H;Iio K;Matsui I;Dono K;Imai E;Monden M;Isaka Y
• 通讯作者: Isaka Y

Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis

PR3-ANCA 相关性肾小球肾炎患者的瓣膜损伤

• DOI: 10.1038/ncpneph0943
• 发表时间: 2008
• 期刊: Nature Clinical Practice Nephrology
• 作者: H. Iwatani;Y. Nagasawa;K. Oka;Y. Isaka;E. Imai
• 通讯作者: E. Imai

リツキシマブが有効であったクリオグロブリン血症の一例

利妥昔单抗有效的冷球蛋白血症一例

• 发表时间: 2010
• 作者: Ohya Y;Okamoto S;Tasaki M;Ueda M;Jono H;Obayashi K;Takeda K;Okajima H;Asonuma K;Hara R;Tanihara H;Ando Y;Inomatal Y;早崎貴洋
• 通讯作者: 早崎貴洋

Lymphangiogenesis Develops during Tubulo-Interstitial Fibrosis Via the TGF-b-VEGF-C Pathway in Rat Unilateral Ureteral Obstruction

大鼠单侧输尿管梗阻中肾小管间质纤维化期间通过 TGF-b-VEGF-C 途径发展淋巴管生成

• 发表时间: 2010
• 作者: Kawamura Y;Matsuo H;Chiba T;Nagamori S;Nakayama A;Inoue H;Utsumi Y;Oda T;Nishiyama J;Kanai Y;外1名;堀内正浩・梶龍兒;Yasuhiro Suzuki
• 通讯作者: Yasuhiro Suzuki

Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: Addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker

• DOI: 10.1291/hypres.31.59
• 发表时间: 2008-01-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Furumatsu, Yoshiyuki;Nagasawa, Yasuyuki;Shoji, Tatsuya
• 通讯作者: Shoji, Tatsuya