Gene expression profile of tonsils of patients with IgA nephropathy

我们使用微阵列分析了伊加肾病患者（N=23）扁桃体中的基因表达，并与那些患有慢性扁桃体炎但无IgAN的患者（N=22）进行了比较。我们确定了12个上调基因，包括APOBEC2，CALB 2，DUSP 27和CXCL 11。APOBEC2在上皮细胞和生发中心周围呈阳性表达。在另外73例IgAN患者中，APOBEC 2在扁桃体中被证实升高。这些结果表明，APOBEC2可能与IgAN的发展。

We analyzed the gene expression in the tonsils of patients with IgA nephropathy (N=23) using microarray, compared with those with patients suffering from chronic tonsillitis without IgAN (N=22). We confirmed12 up-regulated genes including APOBEC2, CALB2, DUSP27, and CXCL11. APOBEC2 was positively stained in the epithelium and the peripheral region of the germinal center. The APOBEC2 was confirmed to be elevated in the tonsils in another 73 IgAN patients. These results suggest that the APOBEC2 might be associated with development of IgAN.