Prostate cancer susceptibility locus 8q24 in the Japanese population.

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This study included probands from 134 familis with familial prostate cancer, 158 with sporadic prostate cancer and 120 with benign prostatic hyperplasia as the control subjects. The SNP marker rs1447295 was genotyped by real-time PCR using Taq-Man^[○!R] SNP genotyping assay. And the microsatellite marker DG8S737 was genotyped using a PCR based assay. There was a significant positive association between the DG8S737-12 allele and familial prostate cancer risk (OR 1.86, 95% CI 1.11-3.00, p=0.02) and a significant association of risk with the rs1447295 A allele (OR 2.36, 95% CI 1.41-3.94, p=0.002). Significant associations were noted for each marker in men with a high Gleason score. Two alleles at 8q24 are genetic risk factors for familial prostate cancer and high grade disease in Japanese population.